Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-137-6 | CAS number: 103-71-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
No data.
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
In a not assignable/limited developmental study pregnant mice were applied 9.8 mg/kg bw phenyl isocyanate on day 4, 7, 11, and 15 of gestation. No effects on numbers of corpora lutea, total implants, living implants, preimplantation, postimplantation and total implantation losses were evident. Therefore phenyl isocyanate is regarded as non embryotoxic. No information with regard to reproductive organs is given in the 28-days inhalation study. Since inhaled phenyl isocyanate vapor will react primarily with lung tissue so that other systemic organ systems or tissues would be affected only at exposure concentrations that produce sufficient lung toxicity. But the propensity of phenyl isocyanate to cause lung effects consequently led to secondary effects such as hypoxia that could influence developmental endpoints. Therefore it is not expected to yield useful information from a reproductive or developmental toxicity study of phenyl isocyanate vapor inhalation. Thus reproductive toxicity cannot be excluded, but it seems to be unlikely at nonirritant phenyl isocyanate exposure concentrations.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Additional information
In a not assignable/limited developmental study pregnant mice were applied 9.8 mg/kg bw phenyl isocyanate on day 4, 7, 11, and 15 of gestation. No effects on numbers of corpora lutea, total implants, living implants, preimplantation, postimplantation and total implantation losses were evident. Therefore phenyl isocyanate is regarded as non embryotoxic. No information with regard to reproductive organs is given in the 28-days inhalation study. Since inhaled phenyl isocyanate vapor will react primarily with lung tissue so that other systemic organ systems or tissues would be affected only at exposure concentrations that produce sufficient lung toxicity. But the propensity of phenyl isocyanate to cause lung effects consequently led to secondary effects such as hypoxia that could influence developmental endpoints. Therefore it is not expected to yield useful information from a reproductive or developmental toxicity study of phenyl isocyanate vapor inhalation. Thus reproductive toxicity cannot be excluded, but it seems to be unlikely at nonirritant phenyl isocyanate exposure concentrations.
Toxicity to reproduction: other studies
Description of key information
No data.
Additional information
No data.
Justification for classification or non-classification
As pointed out in the discussion field, reproductive toxicity is unlikely. According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification seems not justified.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.