Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-462-1 | CAS number: 345-78-8
Endpoint summary
Administrative data
Description of key information
Based on skin (OECD 404) and eye irritation (OECD 405) studies performed in vivo, it can be concluded that the test substance is not corrosive or irritating to the skin and eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
In a skin irritation/corrosion test according to OECD guideline 404, 2 male and 1 female vienna white rabbit were dermally exposed to the test substance for 4 hours under semi-occlusive conditions (BASF 1986). Symptomes such as erythema (very slight to well-defined; all animals) and edema (very slight; two animals) were observed 4 hours after removal of the test substance. The mean value for erythema and for edema was 0 at the other time points (24, 48, 72 h). Based on the conditions of the performed skin irritation/corrosion test the substance is considered to be not irritating.
Eye irritation
The eye irritating potential of the test substance was examined in 2 male and 1 female Vienna White rabbits (OECD TG 405, no GLP). The animals were exposed to about 0.1 mL (37 mg) of test substance, and no rinsing of the eye was performed (BASF 1986). Observations were performed after 1, 24, 48, and 72 h. Conjunctivae redness (well-defined) and chemosis (slight) was observed in all 3 animals after 1h. The mean score (24 to 72 hours) for irritation was calculated to be 0.3, 0, and 0 for corneal opacity, 0, 0, and 0 for iritis, 0.7, 0.3, and 0 for conjunctivae redness, and 0.3, 0, and 0 for chemosis for animal 1, 2, and 3 respectively. Findings were reversible within 48 hours after application.
Justification for selection of skin irritation / corrosion endpoint:
One skin irritation / corrosion study is available. This study is adequate for covering this endpoint.
Justification for selection of eye irritation endpoint:
One eye irritation study is available. This study is adequate for covering this endpoint.
Justification for classification or non-classification
Based on the results obtained in the skin irritation test (according to OECD guideline 404) and the eye irritation test (according to OECD guideline 405) showing very limited effects, classification for skin irritation / corrosion and eye irritation is not warranted in accordance with EU Directive 67/548 (DSD) and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
