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Diss Factsheets
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EC number: 426-620-5 | CAS number: 619297-89-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The following toxicological tests, which provide also some information on the toxicokinetic properties, were conducted on the substance:
LD 50 oral rat
LD 50 dermal rat
skin irritation
rabbit eye
irritation rabbit sensitization (M&K) guinea pig
Ames test
28 day oral (gavage) rat
The substance is obviously absorbed from the gastrointestinal tract to a certain degree as can be concluded from signs of intoxication (both sexes) and lethal effects (only females) at dose levels of 2000 mg/kg bw and above applied by gavage. The dose response curve seems to be relatively steep at doses around 2000 mg/kg bw, since in females 1600 mg/kg did not even induce symptoms of intoxication whereas lethal effects were already seen with an increase of only 400 mg/kg.
There is no particular potential of increased dermal absorption, since no systemic signs of intoxication were seen after occlusive administration of 2000 mg/kg bw to the rat skin. This view is supported by the results of a skin irritation test in rabbits and by an investigation for sensitizing properties in guinea pigs.
The repeated administration (according to the standard treatment schedule) of the compound did not produce signs of systemic intoxication and no allergenic response in guinea pigs.
The results of a 28 day study using gavage administration of 0 (control), 62.5 or 250 or 1000 mg/kg bw indicate rapid elimination of the compound, since the top dose of 1000 mg/kg bw which is roughly half of the oral acute LD50 did not cause treatmentrelated systemic effects. Cumulation can be excluded.
No cytotoxicity was seen in a standard Ames test. Cytotoxicity as observed without metabolic activation at the highest concentrations of 2500 and 3200 ug/ml was slightly reduced in a V 79 system when a rat liver S-9 mix was added in a chromosome aberration assay. It is not clear whether the difference is due to metabolic detoxification or unspecific protective (buffering) activities of the S-9 mix. There was at least no indication that metabolites are formed which are significantly more toxic than the parent compound.
No investigation on metabolism in animals of the monoiodo-aromatic compound is available. However testing of the complete sulfonylurea which is synthesized from this substance indicates that cleavage of the iodo-group does not play a major role during metabolism of the sulfonylures in animals and no depletion of the complete sulfonylurea or of the iodo-containing subparts of the molecule was detected in the thyroid or other organs in absorption, distribution and excretion studies.
Summary: The available biological data and chemical properties of the relatively small and hydrophilic molecule suggest absorption and rapid excretion. No increased potential for dermal absorption or possible cumulative properties were identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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