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Diss Factsheets
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EC number: 930-447-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March to may 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study by a laboratory having a GLP certificate
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate on january 27th 2009
- Type of assay:
- bacterial reverse mutation assay
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Method
- Target gene:
- The objective of the study was to evaluate the potential of the test item EPOXY RESIN T1800 (batch No 81016) to induce reverse mutation in Salmonella typhimurium.
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- DNA polymerase A deficient
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix
- Test concentrations with justification for top dose:
- The test item was freely soluble in the vehicle (DMSO) at 100 mg/mL.
Consequently, with a treatment volume of 50 µL/plate, the dose-levels were 10, 100, 500, 1000, 2500 and 5000 µg/plate
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The number of revertants for the vehicle and positive controls was as specified in the acceptance criteria. The study was therefore considered as valid.
Since the test item was freely soluble and non-toxic in the preliminary test, the highest dose-level retained for the main experiments was 5000 µg/plate, according to the criteria specified in the international guidelines.
The selected treatment-levels were: 312.5, 625, 1250, 2500 and 5000 µg/plate for both mutagenicity experiments with and without S9 mix.
No precipitate was observed in the Petri plates when scoring the revertants at any of the tested dose-levels.
No noteworthy toxicity was noted towards the tester strains used, either with or without S9 mix.
A slight increase in the number of revertants (2.6-fold the vehicle control value) was noted in the TA 1537 strain in the first experiment with S9 mix (direct plate incorporation method).This increase did not reach the threshold value of 3-fold the vehicle control value but was dose-related. In the second experiment performed using the preincubation method, a noteworthy (up to 4.1-fold the vehicle control value) increase in the number of revertants was observed. Since this increase exceeded the threshold of positivity and was dose-related, it was considered as biologically relevant.
Noteworthy increases in the number of revertants were noted in the TA 102 strain in both mutagenicity experiments with S9 mix. Since these increases exceeded the threshold value of 2- fold the vehicle control value and since they were reproducible, they were considered as biologically relevant.
Noteworthy increases in the number of revertants were noted in the TA 1535, TA 98 and TA 100 strains in both mutagenicity experiments with and without S9 mix. Since these increases exceeded the threshold value of positivity (3-fold the vehicle control value for the TA 1535 and 2‑fold the vehicle control value for the TA 98 and TA 100 strains) and since they were reproducible and generally dose-related, they were considered as biologically relevant.
Conclusion
Under our experimental conditions, the test item EPOXY RESIN T1800 (batch No. 81016) showed mutagenic activity in the bacterial reverse mutation test with Salmonella typhimurium, in presence and in absence of a rat metabolizing system.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
ambiguous
Under our experimental conditions, the test item EPOXY RESIN T1800 (batch No. 81016) showed mutagenic activity in the bacterial reverse mutation test with Salmonella typhimurium, in presence and in absence of a rat metabolizing system.
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