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EC number: 217-121-1 | CAS number: 1745-89-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Date of acclimatization: 27 November 1985; Date of application: 3 December 1985 ; Date of completion: 17 December 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP methodology followed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4,4'-isopropylidenebis[2-allylphenol]
- EC Number:
- 217-121-1
- EC Name:
- 4,4'-isopropylidenebis[2-allylphenol]
- Cas Number:
- 1745-89-7
- Molecular formula:
- C21H24O2
- IUPAC Name:
- 4-{1-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]propyl}-2-(prop-2-en-1-yl)phenol
- Test material form:
- other: viscous liquid
- Details on test material:
- - Identification: TK 11907
- Batch: Op. 1
- Generic name: XU 292 B
- Stability: Guaranteed by the sponsor, until October 1991
- Storage conditions: Room temperature
- Description: Viscous liquid
- Purity: Pilot sample
- Test article received: 19 November 1985
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Rat, Tif: RAIf(SPF), F3-hybrid of Ril 1/TIF x Ril 2/Tif
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- -RationaIe: The rat has been selected for this test as being a Standard species for the determination of an acute dermal LD50.
- Source: CIBA-GEIGY LTD. Tierfarm, 4334 Sisseln, Switzerland
- Initial Body Weight Range: 203 - 242 g
- Initial Age: 7-8 weeks
- Tndividual Identification: By cage number
- Husbandry: The animals were kept under conventional laboratory conditions. They were caged individually in Macroion cages type 2 with standardized soft wood bedding (Societe Parisienne des sciures, Pantin).
The animal room was air conditioned: temperature 22±3° C, relative humidity 55±15%, 12 hours light/day, approximately 15 air changes/h.
- Diet: Rat food, NAFAG No. 890, NAFAG AG, Gossau, SG (Switzerland),and water were provided ad libitum.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- Liquid substance, used undiluted.
- Details on dermal exposure:
- - Volume (ml/kg body weight) applied: 2
- Pretreatment: Approximately 24 hours before treatment an area on the back of the rat of at least 10% of the body surface was shaved with an
electric clipper.
- Application: The required amount of the test substance was evenly dispersed on the skin. It was covered with a gauze-lined semiocclusive dressing, which was fastened around the trunk with an adhesive elastic bandage.After an exposure period of 24 hours the dressing was removed and the skin was cleaned with lukewarm water. Thereafter the reaction of the skin was appraised repeatedly.
days - Duration of exposure:
- One single dose, applied onto the skin of the back.
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females (in total 10 rats)
- Control animals:
- other:
- Details on study design:
- - Duration of observation period following administration: 14 days
- Mortality: daily, a.m. and p.m. on working days, a.m. on weekends
- Signs and Symptoms: daily
- Body weight: on days 1, 7, and 14
- Necropsies: The animals were submitted to a gross necropsy at the end of the observation period. - Statistics:
- From the body weights, the group means and their Standard deviations were calculated.
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: Dyspnea, ruffled fur, and abnormal body positions were seen, being common symptoms in acute tests. Additionally, erythema reactions were observed from day 1 to day 8 after the application and edema reactions from day 4 to day 8 after the application. The
- Other findings:
- Autopsie: No deviations from normal morphology were found.
Any other information on results incl. tables
Signs and symptoms:
Observations | Exposure day: hours | Day of post-exposure period | ||||||||||||||||
Observation | 1 | 2 | 3 | 5 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | >13 |
2000 mg/kg | ||||||||||||||||||
Dyspnea | XX | XX | XX | XX | X | X | X | X | X | X | X | X | X | X | X | X | ||
Ruffled fur | X | X | X | X | X | X | X | X | X | X | X | X | X | |||||
Body position ventral | X | X | X | X | X | |||||||||||||
Body position curved | X | X | X | X | ||||||||||||||
Erythema | X | X | X | X | ||||||||||||||
Edema | X | X | X | X | X |
X=slight XX=moderate XXX=marked
Body weight and standard deviations:
Males | |||
dose mg/kg | Day 1 | Day 7 | Day 14 |
2000 | 211/5.5 | 256/8.5 | 305/12.1 |
Females | |||
Dose mg/kg | Day 1 | Day 7 | Day 14 |
2000 | 216/15.2 | 214/13.4 | 226/9.8 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Upon an acute dermal application and a 14 day post-treatment observation period, the following LD50 (with 95% confidence limits calculated where possible) was determined for TK 11907.
- Executive summary:
The study, project no. 851048, was conducted to determine the acute dermal toxicity of TK 11907 in albino rats.
All the work was done at the Sisseln facility (CH-4332 Stein/Switzerland).
This experiemnt was performed according to the OECD 405.
Upon an acute dermal application and a 14 day post-treatment observation period, the following LD50 (with 95% confidence limits calculated where possible) was determined for TK 11907.
LD50 in male rats; > 2000 mg/kg bw.
LD50 in female rats: > 2000 mg/kg bw.
LD50 in rats of both sexes: > 2000 mg/kg bw.
Symptoms
Dyspnea, ruffled fur, and abnormal body positions were seen, being common symptoms in acute tests.
Additionally, erythema reactions were observed from day 1 to day 8 after the application and edema reactions from day 4 to day 8 after the application.
The animals recovered within 13 days.
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