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Diss Factsheets
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EC number: 218-915-0 | CAS number: 2280-49-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study planned
- Justification for type of information:
- TESTING PROPOSAL ON TERRESTRIAL MICROORGANISMS, OECD 216
NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Name of the substance on which testing is proposed to be carried out: N-phenyl-N-[(trichloro-methyl)thio]benzene-sulphonamide (CAS 2280-49-1)
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- Available GLP studies: For N-phenyl-N-[(trichloro-methyl)thio]benzene-sulphonamide (CAS 2280-49-1) no studies assessing the toxicity on terrestrial microorganisms are available yet.
- Available non-GLP studies: No further studies on terrestrial toxicity on microorganisms are available for N-phenyl-N-[(trichloro-methyl)thio]benzene-sulphonamide (CAS 2280-49-1)
- (Q)SAR: There are no QSAR models available for this higher tier ecotoxicological endpoint that are sufficiently validated and acceptable (according to OECD Q/SAR validation criteria).
- Weight of evidence & Grouping and read-across: N-phenyl-N-[(trichloro-methyl)thio]benzene-sulphonamide (CAS 2280-49-1) is not part of a category and no data on terrestrial toxicity on microorganisms for N-phenyl-N-[(trichloro-methyl)thio]benzene-sulphonamide (CAS 2280-49-1) or related substances is available. There is thus no data supporting a weight of evidence or read-across approach and further testing is deemed necessary.
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- As described in REACH Guidance document R7.c, Version 3.0 (June 2017) soil hazard category 3 applies for N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide: The substance is not readily biodegradable. There is no indication that the substance is very toxic to aquatic organisms. The experimentally determined partition coefficient (logKOW: 4.7) and the soil adsorption coefficient (logKOC: 4.5) are both indicative for an adsorptive potential of the substance.
According to Table R.7.11-2 soil category 3 requests to apply the EPM approach as well as to conduct a confirmatory long-term soil toxicity study. For N-phenyl-N-[(trichloromethyl)thio]benzenesulphon-amide it is, however, not possible to apply the EPM approach as no effects were determined in acute and chronic studies up to the limit of water solubility. The conclusion in accordance with REACH Guidance Document R.10 was, therefore, “no hazard identified” and no PNEC aqua was derived. In order to fulfill the requirements according to Table R.7.11-2, a confirmatory long-term toxicity test for terrestrial invertebrates according to OECD TG 222 Earthworm Reproduction Test was conducted and used to calculate the PNEC soil. The trophic level of invertebrates was investigated as it was considered as most relevant.
Recent experimental results from an earthworm reproduction test indicate toxicity of N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide towards the terrestrial compartment. It is therefore required to assess the toxicity towards other terrestrial compartments. According to REACh Regulation (EC) No. 1907/2006, Annex IX, 9.4, column 2 and ECHA Guidance R.7c (2017), long-term terrestrial studies are recommended for compounds with high potential for adsorption to soil.
The registrant has carefully considered the available adaptation possibilities applicable for the discussed endpoint. Based on the lack of data on toxicity testing on terrestrial plants and the recommendations in ECHA Guidance R.7c (2017), it is deemed necessary to further investigate the long-term toxicity potential of the substance.
FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- The registrant intends to perform the toxicity on soil microorganisms according to OECD TG 216, Soil Microorganisms: Nitrogen Transformation Test. According to the guideline, the study design of this study will fit to the physico-chemical properties of the test substance, as this study can deal with substances with low water solubility and prone to hydrolysis.
Data source
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)
Test material
- Reference substance name:
- N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide
- EC Number:
- 218-915-0
- EC Name:
- N-phenyl-N-[(trichloromethyl)thio]benzenesulphonamide
- Cas Number:
- 2280-49-1
- Molecular formula:
- C13H10Cl3NO2S2
- IUPAC Name:
- N-phenyl-N-[(trichloromethyl)sulfanyl]benzenesulfonamide
Constituent 1
- Specific details on test material used for the study:
- Test material with a high degree of purity will be used.
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.