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EC number: 216-904-5 | CAS number: 1694-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- The acute toxicity and primary irritancy potential of the test chemical
- Author:
- Bryan Ballantyne et.al
- Year:
- 1 986
- Bibliographic source:
- Drug and Chemical Toxicology, 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To determine the primary dermal irritation potential of the test chemical in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- 2,4-Pentadione
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report):2,4-Pentandione- Molecular formula :C5H8O2- Molecular weight : 100.116 g/mol- Substance type:Organic- Physical state:Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Details on test animalTEST ANIMALS- Weight at study initiation: 2.0-3.0 kgENVIRONMENTAL CONDITIONS- Temperature (°C): 68-75 deg C- Humidity (%):30-65%- Photoperiod (hrs dark / hrs light): A 12 hr light-dark cycle was used in the animal accommodation rooms.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1 hours and 1, 2,3,7, 14 days post instillation
- Number of animals:
- 6
- Details on study design:
- Details on study designTEST SITE- Area of exposure: clipped dorsal skin- % coverage: no data available- Type of wrap if used: gauze and impervious polyethylene sheetingREMOVAL OF TEST SUBSTANCE- Washing (if done): yes- Time after start of exposure: after 4 hours of exposureSCORING SYSTEM: erythema and edema were scored by the method of Draize
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 0
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- 5 of 6 rabbits had a very slight local erythema, which also developed in the sixth animal by 24 hr. Edema, slight in 5 rabbits and moderate in one, was also present. After 3 days, only half the animals had just detectable erythema, and one had mild edema. Apart from mild desquamation, no effects were seen at 7 days.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- 5 of 6 rabbits had a very slight local erythema, which also developed in the sixth animal by 24 hr. Edema, slight in 5 rabbits and moderate in one, was also present. After 3 days, only half the animals had just detectable erythema, and one had mild edema. Apart from mild desquamation, no effects were seen at 7 days.Since the effects were completely healed by 7 days, the test chemical can be considered to be not irritating to skin.
- Executive summary:
A study was performed to determinethe primary dermal irritation potential of the test chemical in rabbits.
0.5 ml undiluted test chemical was applied to the clipped dorsal skin of 6 New Zealand White rabbits under occlusive wrapping for 4 hours. After 4 hours of exposure, the occlusive dressing was removed and the excess test chemical was gently removed. The test sites were inspected for erythema and edema at 1 hour, 1, 2, 3, 7 and 14 days post removal of the dressing. The dermal reactions were scored by the methods of Draize.
5of6rabbits had a very slight local erythema, which also developed in the sixth animal by 24 hr. Edema, slight in 5 rabbits and moderate in one, was also present. After 3 days, only half the animals had just detectable erythema, and one had mild edema. Apart from mild desquamation, no effects were seen at7days.
Since the effects were completely healed by 7 days, the test chemical can be considered to be not irritating to skin.
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