Registration Dossier
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EC number: 220-971-6 | CAS number: 2950-43-8
Endpoint summary
Administrative data
Description of key information
Additional information
Since data for the test substance hydroxylamine-O-sulphonic acid (CAS 2950-43-8) are not available (except for toxicity in microorganism), results of the surrogate substance bis(hydroxylammonium) sulfate (CAS 10039-54-0) are used in a reliable read-across approach to evaluate the test substance.
Under relevant pH conditions as typically met in most surface waters (pH 7-9), hydroxylamine is almost entirely abundant as uncharged molecule (see also Chapter 4.21). Therefore, the hazard assessment of hydroxylamine and its salts can be considered as the hazard assessment of hydroxylamine, exclusively. Toxicity of the corresponding anion of Bis(hydroxylammonium) sulphate or Hydroxylammonium, hydrochloride may be neglected since toxicity values for various relevant salts, such as NaCl or Na2SO4, have been shown to be far greater than 100 mg/L (e.g. Mount et al. 1997). BASF AG (2007)
Data are available concerning the short-term effects on fish, daphniae and algae for Bis(hydroxylammonium)sulphate. However, most of the information is not completely reliable and can only be used as indicative information. Furthermore, a highly reliable chronic test is available, examining daphnia in a semistatic system.
Based on the results for the surrogate substance, as acute LC50 (fish) 7.2 mg/L were estimated (NAPM, 1974) with Pimephales promelas as test organism. With Daphnia magna as test organism, as EC50 (48 h) 1.6 mg/L were calculated for invertebrates (BASF AG 1988a). Concerning long-term toxicity, for Daphnia magna a NOEC of as 0.31 mg/L was deemed, based on measured concentrations (BASF AG, 2007). In a test with Scenedesmus subspicatus, based on the growth rate a 72-h EC50 of 1.318 mg/L and for a 72-h NOEC of 0.312 mg/L were estimated (BASF, 2007). Furthermore, in an Activated Sludge Respiration Inhibition Test, for the test substance the EC20 (30 min) was determined as ca. 450 mg/L and the EC50 as > 1000 mg/L (BASF, 2004).
BASF AG (2007). Expert judgement. Department of product safety, 1 Aug 2007, Mount DR et al. (1997). Statistical models to predict the toxicity of major ions to Ceriodaphina dubia, Daphina magna and Pimephals promelas. Environm Toxicol Chemistry 16: 2009-2019.
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