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Diss Factsheets
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EC number: 203-139-7 | CAS number: 103-73-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from handbooks and authoritative databases
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Patty's Industrial Hygiene and Toxicology- Phenetole
- Author:
- Frank Arthur Patty, George D Clayton, Florence E Clayton
- Year:
- 1 981
- Bibliographic source:
- Patty's Industrial Hygiene and Toxicology- Phenetole, 6th Edition, 2012
- Reference Type:
- review article or handbook
- Title:
- DOSE Doc. no.: P73
- Author:
- S.D Gangolli
- Year:
- 1 999
- Bibliographic source:
- The Dictionary of Substances and their Effects (DOSE), Edited by S D Gangolli, Second Edition, pg 204, 1999
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB for the test material
- Author:
- US National Library of Medicine reviewed by SRC
- Year:
- 2 011
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US National Library of Medicine reviewed by SRC, 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the dermal irritation potential of the test chemical
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenetole
- EC Number:
- 203-139-7
- EC Name:
- Phenetole
- Cas Number:
- 103-73-1
- Molecular formula:
- C8H10O
- IUPAC Name:
- ethoxybenzene
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Phenetole
- Molecular Formula: C8H10O
- Molecular Weight: 122.17 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Phenetole
- Molecular Formula: C8H10O
- Molecular Weight: 122.17 g/mol
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Not available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- Not available
- Duration of treatment / exposure:
- Not available
- Observation period:
- Not available
- Number of animals:
- Not available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: no data available
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Signs of slight irritation were observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
Administration of the test chemical to the rabbit resulted in a slight skin irritation effect which is not adequate for classification as a skin irritant. Therefore, it can be concluded that the test chemical was not irritating to skin.- Executive summary:
Administration of the test chemical to the rabbit resulted in a slight skin irritation effect which is not adequate for classification as a skin irritant. Therefore, it can be concluded that the test chemical was not irritating to skin.
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