Registration Dossier
Registration Dossier
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EC number: 259-700-1 | CAS number: 55542-26-2
Endpoint summary
Administrative data
Description of key information
No internal Guideline skin irritation study was conducted.
However, within an acute dermal toxicity study in rats also local findings were recorded and evaluated (Rat, TG OECD 402): not skin irritating
[Schering AG, Report No. X548 -draft-, 2001-02-27]
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The single dermal administration of the test substance (ZK 4829) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related local findings were observed. The mean values of findings at the time-points 1, 24, 48 and 72 h after administration were 0 for swelling, reddening and scab formation. Although the acute dermal toxicity study was with respect to skin irritation / corrosion not conducted according to current guidelines and with the most sensitive species rabbit Hydroxypropinol can be regarded as not irritating to the skin since 24 h exposure to the test substance (instead of 4 h) was tolerated by 6 rats (instead of 3 animals) without any local skin reactions.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
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