Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 425-950-7 | CAS number: 187393-00-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Not a skin irritant
Not an eye irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
The potential of Bemotrizinol to induce skin irritation was evaluated in 3 New Zealand White rabbits (RCC 651431, 1997, OECD 404, GLP). A single dose of 500 mg of the test item in its original form was applied semi-occlusively to the closely-clipped skin of one flank. No cutaneous reactions were observed approximately 1 hour, 24, 48 and 72 hours after removal of the dressing. Mean scores over 24, 48 and 72 hours for each animal were 0.0, 0.0 and 0.0 for erythema and 0.0, 0.0 and 0.0 for edema. Under the experimental conditions employed, the test item was non-irritant when applied topically to rabbits.
Eye irritation:
The potential of Bemotrizinol to induce ocular irritation was evaluated in the key study in rabbits (RCC 651442, 1997, OECD 405, GLP). A single dose of 100 mg of the test item in its original form was introduced into the left conjunctival sac of the eye of three New Zealand White rabbits. The right eye was not treated and served as control. Ocular reactions were observed approximately 1 hour, 24 and 48 hours after the administration. Mean scores calculated for all animals over 24, 48 and 72 hours was 0.44 for redness of the conjunctiva. Other parameters such as corneal opacity, iritis, chemosis were not affected by treatment within 24 -72 hours. Under the experimental conditions employed Bemotrizinol was non irritant when administered by ocular route to rabbits.
Supportive in vitro studies are available to assess the eye damage and irritation potential of Bemotrizinol. In a Bovine Corneal Opacity and Permeability (BCOP) test, 3 corneas were treated with a 20% Bemotrizinol preparation in de-ionized water for an exposure period of 4 hours (BASF 2012; 63V0382/10A438). The in vitro irritancy score (IVIS) for Bemotrizinol was determined to be 6.6 (+/-5.1) and thus, the substance was identified to cause no serious eye damage according to the respective prediction model. The eye irritation potential of Bemotrizinol was determined in an EpiOcular™ eye irritation test via incubation of 2 tissue samples with the undiluted test substance for 90 minutes followed by an 18-hour post-incubation period (BASF 2012; 62V0382/10A242). Mean tissue viability after treatment with Bemotrizinol was 104% compared to the negative control (deionized water). Accordingly, Bemotrizinol did not show any eye irritation potential in this test system under the conditions chosen.
Justification for classification or non-classification
The present data on skin and eye irritation do not fulfill the criteria laid down in regulation (EU) 1272/2008, and therefore, a non-classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.