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EC number: 700-213-5 | CAS number: 947753-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 50
- PNEC freshwater (intermittent releases):
- 0 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0 mg/L
- Assessment factor:
- 500
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 100 mg/L
- Assessment factor:
- 10
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.962 mg/kg sediment dw
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.096 mg/kg sediment dw
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.192 mg/kg soil dw
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 66 700 mg/kg food
- Assessment factor:
- 300
Additional information
Reliable test data are available for the three principle trophic levels: primary producers, represented by algae; plant eating animals, represented by daphnids; and predators, represented by fish. In the case of the current chemical, long-term studies are represented by an algal study and by a 21 -day study in Daphnia magna (see Guidance on Information Requirements and Chemical Safety Assessment. Chapter R.10, May 2008). All of these studies represent freshwater species. For the purpose of setting a PNEC value for freshwater aquatic organisms, the most appropriate starting value is the NOEL of 0.0048 mg/L obtained in the study with daphnids. Given that two trophic levels are represented with long-term study results (algae and daphnids), an assessment factor of 50 is applied. Similarly, an assessment factor of 500 is applied to the NOEL from daphnids to obtain the PNEC value for marine aquatic organisms.
Given the lack of a measured LC50 value in an aquatic species, the PNEC vlaue for intermittent releases was set as 1/10 of the NOEC value from the daphnid study.
Based on the NOEC of 1000 mg/L (nominal) from an activated sludge inhibition test, a PNEC STP value of 100 mg/L was determined.
No reliable test data for sediment organisms have been identified for the subject chemical. PNEC values for this environmental compartment are calculated using the Equilibrium Partitioning Method (EPM) that uses both PNEC values for aquatic organisms and estimations of environmental partitioning based on physico-chemical properties. The following equation is recommended for the estimation of a PNEC value for sediment organisms (see Guidance on Information Requirements and Chemical Safety Assessment. Chapter R.10, Section R.10.5.2.1 and Equation R.10-2, May 2008):
PNECfreshwater sediment= Ksusp. solids-water/RHOsusp solidsx PNECfreshwaterX 1000
Where, K is the partition coefficient for suspended solids and water (units of m3/m3), RHO is the bulk density of wet suspended solids (1150 kg/m3in this case), and PNECfreshwater is as calculated previously.
The partition coefficient, K, and the PNECfreshwater sediment value wereobtained from the EUSES Program (Ver. 2.1) with the following inputs:
Molecular Weight = 391.51 g/mole
Vapor Pressure = 2.0E-05 Pa (at 25 °C)
Water Solubility = 0.04 mg/L
Octanol-Water Partition Coefficient (log, estimated) = 6.05
The EUSES program provided the following values:
PNECfreshwater sediment= 0.962 mg/kg of dry wt.
PNECmarine-water sediment= 0.0962 mg/kg of dry wt
There are no available terrestrial effects testing results for the subject chemical for any soil-dwelling organism. Based on the safety assessment guidance for this endpoint (Chapter R.7c, R.7.11.5.3), extrapolating aquatic toxicity data using the Equilibrium Partitioning Method is recommended. In the same way as the above PNEC values for sediment were obtained, a PNECsoil value was calculated using the EUSES program (see Guidance on Information Requirements and Chemical Safety Assessment. Chapter R.10, Section R.10.6.1 and Equation R.10-5, May 2008). The EUSES program gave the following:
PNECsoil= 0.192 mg/kg dry wt.
There is no available information on the long-term or reproductive toxicity of the subject chemical to birds (see REACH, Annex X). However, appropriate information is available from repeated-dose studies in mammalian species. For the calculation of an environmental PNECoral value for the subject chemical, an NOAEL value of 1000 mg/kg bwt/day, obtained in a sub-chronic rat oral gavage study (OECD Guideline 422), served as the starting point. This was used to calculate a PNECoral value (see Guidance on Information Requirements and Chemical Safety Assessment. Chapter R.10, Section R.10.8.2).
A NOECrat,food(kg/kgfood) is obtained from the following equation:
NOECrat,food= NOAELratx CONVrat
(NOAELratin units of kg/kg bwt/d)
CONVrat= 20 (g body wt / g daily food intake)
(for rat > 6 weeks of age)
Therefore,
NOECrat,food= 1.0 x 10 -3kg/kg bwt/d x 20 = 20 x 10 -3 kg/kgfood
An assessment factor of 300 (for the sub-chronic rat study) was applied to this NOEC value to give the final PNECoral (see Guidance on Information Requirements and Chemical Safety Assessment. Chapter R.10, Section R.10.8.2 and Table R.10-13).
PNECoral= 20 x 10 -3/ 300 = 0.0667 x 10 -3 kg/kgfood
or 66,700 mg/kgfood
Conclusion on classification
Based on the lack of a measured acute (LC50/EC50) value for the subject chemical, it is not classifiable for acute aquatic toxicity hazard in accordance with Directive 67/548/EEC and EU CLP (Regulation (EC) No. 1272/2008).
Category 1 is the only classification for acute toxic hazard, aquatic toxicity adopted by the EU CLP (Regulation (EC) No. 1272/2008), and the subject chemical does not meet this criterion for classification. UN GHS adopts additional categories of acute aquatic toxicity. However, these are all based on LC50/EC50 values at or below the water solubility. Therefore, in non-EU countries that adopt UN GHS, the subject chemical would not meet the criteria to be classified as an Acute Aquatic Hazard.
Similarly, the subject chemical is not subject to classification under the EU CLP criterion for Chronic categories 1, 2 or 3, based on the lack of a measured LC50/EC50 value in an aquatic species. Also, given the subject chemical's presumed low potential for bioaccumulation, it is not classified as Chronic Category 4 under the EU CLP criterion or under the UN GHS classification system.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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