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Diss Factsheets
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EC number: 420-670-1 | CAS number: 37443-42-8 METHFAT
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 9 April 1990 to 25 April 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to international guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl tetrahydro-2-furancarboxylate
- EC Number:
- 420-670-1
- EC Name:
- Methyl tetrahydro-2-furancarboxylate
- Cas Number:
- 37443-42-8
- Molecular formula:
- C6H10O3
- IUPAC Name:
- methyl oxolane-3-carboxylate
- Test material form:
- other: liquid
- Details on test material:
- Identification: Methfat
Source: QO Chemicals, Inc. P.O. Box 2500 West Lafayette, Indiana 47906
Date received: February 23, 1990
Reference number: PP17-9J29
Purity: Assume 100% for acute testing
Physical description: Clear colourless liquid
Storage conditions: sealed container at room temperature
Test material preparation:
A sufficient amount of test material to dose all animals was transferred from the original container to a labeled vial that was covered and transported to the animal room for dosing. The vial contained a stir bar and was amintained on a magnetic stir plate proir to dispensation and throughout the dosing procedure.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Number on study: Fifteen males and fifteen females
- Body weight range: 211 to 244 grams at study initiation
- Age at start of study: young adult
- Method of identification: eartag
- Housing: Individual suspended wire-mesh cages. The animals were maintained by the animal husbandry staff of Wil Research Laboratories, Inc. in accordance with standard operating procedures.
- Quarantine: The animals were acclimated to laboratory conditions for a minimum of 7 days prior to study initiation.
- Food and water: Purina Certified Rodent Chow #5002 and tap water from on-site wells. Analysis of feed is performed and provided by the manufacturer. Water is analyzed twice yearly in accordance with S.O.P. No. A-20.
- Environmental conditions: Animal room with controlled temperature (68-75 °F), humidity (32-68%) and light (12 hours light/12 hours dark). There were approximately 10 fresh air changes per hour.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Method of test material administration
The test material was dosed undiluted as received based on density (specific gravity). The dose volume was determined by dividing the dosage level, expressed in g/kg, by the specific gravity (1.18 g/ml, as provided by the sponsor). Individual doses were calculated based on body weights taken just prior to dosing and the appropriate dose volume.
The test material was administrated orally via gastric intubation with snub-tipped oral dosing needles (16-gauge) which were affixed to one milliliter syringes. the rats were fasted 18-20 hours prior to dosing and returned to feed approximately 3-4 hours after dosing. - Doses:
- 2893, 3500 and 4235 mg/kg
- No. of animals per sex per dose:
- 5 males and fives females
- Details on study design:
- Mortality
The rats were observed at 1.0, 3.0 and 4.0 hours post-dose on day 0 and twice daily thereafter for 14 days.
Clinical observations
The rats were observed at 1.0, 3.0 and 4.0 hours post-dose on day 0 and once daily thereafter for 14 days.
Body weights
Study days -1, 0, 7 and 14 and at death.
Necropsy:
Upon study termination surviving rats were sacrificed by carbon dioxide asphyxiation. The major organ systems of the cranial, thoracic and abdominal cavities were examined for all animals. - Statistics:
- The LD50 values and slopes (with 95% confidence limits) were calculated bu the method of Litchfield and Wilcoxon.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 410 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 855 - 4 073
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 027 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 658 - 3 447
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 217 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 2 921 - 3 542
- Mortality:
- Approximately two-thirds of the rats died (19/30); eleven of these were female. All deaths occurred within two days of dosing. There were two deaths on day 0 and ten and seven rats were found dead on days 1 and 2, respectively.
All rats that survived appeared normal by day 6 or earlier and throughout the remainder of the study. - Clinical signs:
- other: The majority of clinical observations occurred early in the study period, generally on days 0-2. Bradypnea was present for essentially all animals (28/30). Hypoactivity, impaired equilibrium and clear ocular discharge were observed for two-thirds or more
- Gross pathology:
- Stomach abnormalities (reddened mucosa, dark red areas or contents, gray mucosa) and clear red fluid contents in the urinary bladder were observed for 11/19 rats that died. Dark red adrenal glands, a typical agonal change, were present in approximately one-half of the rats that died. Dense white regions in one or both eyes were noted for six rats. Four dead rats had hemorrhagic thymus glands. Other findings noted each for two rats were dark red kidneys, a reddened pituitary gland and dark red intestinal contents. In addition, approximately one-half of the rats that died had various external matting.
There were no significant changes observed for all tissues examined for all rats that were terminally sacrificed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD 50 value of Methfat was found herein to be 3217 mg/kg with 95 % confidence limits of 2921-3542 mg/kg when administered orally via gastric intubation to fasted male and female albino rats.
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