Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-823-0 | CAS number: 10377-52-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Since no information is available regarding acute oral toxicity of trilithium orthophosphate, read-across has been performed to lithium chloride (CAS# 7447-41-8), representing another lithium salt; and to trisodium orthophosphate (CAS# 7601-54-9), representing another alkali phosphate.
Concerning this endpoint, the lithium ion is considered to be the main toxophore, as phosphate ions are widely distributed throughout the organism (e.g. as structural material of bone and teeth and in form of adenosine phosphates ADP and ATP).
With regard to the fact, that trilithium orthophosphate is slightly soluble in water (0.27 g/L), read-across to a more soluble lithium salt (representing a higher bioavailability) can be justified.
There is one study summary for acute oral toxicity with trisodium orthophosphate (CAS# 7601-54-9) publicly available on the ECHA (European Chemicals Agency) homepage. This study was performed according to OECD Guideline 420 and showed that the LD50 of trisodium orthophosphate is higher than 2000 mg/kg bw.
In a review article by Petersen (Acta Pharmacologica et Toxicologica 47, 351 - 354, 1980), the LD50 (male, oral route) for lithium chloride was determined to be 526 mg/kg bw.
Based on a weight of evidence approach, trilithium orthophosphate is classified as Xn, R22, harmful if swallowed in accordance to Directive 67/548/EEC; Acute Toxicity Cat. 4, H302, harmful if swallowed in accordance to EU CLP (Regulation (EC) No. 1272/2008) and UN GHS.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
