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EC number: 810-688-1 | CAS number: 14034-59-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, similar to guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Sprague-Dawley rats were exposed the test substance dissolved in water via oral gavage. After an observation period of 14 days the surviving animals were necropsied and an LD50 was determined.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethylenediamine
- EC Number:
- 203-468-6
- EC Name:
- Ethylenediamine
- Cas Number:
- 107-15-3
- IUPAC Name:
- ethane-1,2-diamine
- Details on test material:
- - Name of test material (as cited in study report): Ethylenediamine
- Structural formula: H2NCH2CH2NH2
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hagemann
- Fasting period before study: 15 - 20 h
- Diet: Herilan MRH; H.Eggermann KG
-Weight at study initiation: Mean of different dose groups: Males: 140-300g; Females: 160-220g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 3.16, 4.64, 6.81, 8.25, 10, 12.1, 14.7 % (w/v)
- Administration volume: 10 mL/kg - Doses:
- 316, 464, 681, 825, 1000, 1210, 1470 mg/kg
- No. of animals per sex per dose:
- - 316, 464, 681 mg/kg: 5
- 825, 1000, 1210, 1470 mg/kg: 10 - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 841 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 683 - 943
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 893 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 750 - 1 001
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 866 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 762 - 946
- Mortality:
- - No mortality observed in animals exposed to 316, 464 or 681 mg/kg.
- 6 out of 10 male and 5 out of 10 female animals died exposed to 825 mg/kg.
- 8 out of 10 male and 7 out of 10 female animals died exposed to 1000 mg/kg.
- 9 out of 10 male and 8 out of 10 female animals died exposed to 1210 mg/kg.
- 9 out of 10 male and all female animals died exposed to 1470 mg/kg. - Clinical signs:
- other: - Dyspnea, spasmodic respiration, apathy, abnormal position, staggering, spastic gait, piloerection, diarrhea, cyanosis, exsiccosis, and a poor general state were observed in animals exposed to 1470 mg/kg. The surviving animal was without symptoms after 2
- Gross pathology:
- - Animals that died: Heart: acute dilatation on the right side; acute congestion; Stomach: diffuse reddening of the glandular stomach; Intestine: in individual animals diarrheal content; atonic; reddened in several cases; Liver: in some animals individual focal necrosis; Thymus: in individual animals extensive hemorrhages.
- Sacrificed animals: Stomach: in several animals wall of the forestomach slightly indurated. In individual cases adhesion of the forestomach to the liver.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this test, the LD50 was determined to be 841, 893, and 866 mg/kg bw for male, female rats and all rats combined, respectively.
- Executive summary:
Five Sprague-Dawley rats per sex per dose were exposed to 316, 464 or 681 mg/kg bw of the test substance dissolved in water via oral gavage. Ten Sprague-Dawley rats per sex per dose were exposed to 825, 1000, 1250 or 1470 mg/kg. After an observation period of 14 days the surviving animals were necropsied. Dyspnea, spasmodic respiration, apathy, abnormal position, staggering, spastic gait, orange-yellow urine, piloerection, diarrhea, cyanosis, exsiccosis, salivation, blood in the feces and a poor general condition were observed amongst exposed animals. Acute dilation on the right side and acute congestion of the heart, diffuse reddening of the glandular stomach, diarrheal content, atonic and reddened intestine in several cases, and extensive hemorrhages of the thymus were observed amongst animals that died upon necropsy. In several sacrificed animals a slightly indurated forestomach and adhesion of the forestomach to the liver were observed upon necropsy. The LD50 was determined to be 841 and 893 mg/kg bw for male and female rats, respectively. The LD50 was determined to be 866 mg/kg bw for male and female animals combined.
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