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Diss Factsheets
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EC number: 241-866-1 | CAS number: 17927-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Skin sensitisation. Multicase model A33.
- GLP compliance:
- not specified
- Type of study:
- other: GPMT or human experience
- Species:
- other: Guinea pig or human
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: no data
- Vehicle:
- no data
- Route:
- other: no data
- Vehicle:
- no data
- Vehicle:
- unchanged (no vehicle)
- Reading:
- 1st reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Clinical observations:
- Non sensitising
- Remarks on result:
- other: Reading: 1st reading. Group: test group. No with. + reactions: 0.0. Clinical observations: Non sensitising.
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Skin sensitization of bis(pentane-2,4-dionato-O,O')zinc is estimated as negative.
- Executive summary:
Skin sensitization of bis(pentane-2,4-dionato-O,O')zinc is estimated as negative.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitisation-
Based on the data reviewed of readacross for the sensitisation and considering the weight of evidence approach following was inferred-
Sr. No
End point
effect
Species
Remark
1.
Skin sensitisation
not sensitizing
Guinea pig or human
DEPA RA - 14024-63-6
2.
Skin sensitisation
not sensitizing
Guinea pig or human
DEPA RA- 3264-82-2
Both the read across values for the target, bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium, indicate that the substance do not have sensitising effect on skin and so based on the weight of evidence of these read across substances it can be inferred that the target substanceas well will be non sensitising to skin.
Migrated from Short description of key information:
Bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium is non sensiting to skin based ont eh weight of evidence of two read across values.
Justification for selection of skin sensitisation endpoint:
Both the read across values for the target, bis(pentane-2,4-dionato-O,O')bis(propan-2-olato)titanium, indicate that the substance do not have sensitising effect on skin and so based on the weight of evidence of these read across substances it can be inferred that the target substanceas well will be non sensitising to skin.
Justification for classification or non-classification
Bis (pentane-2,4-dionato-O,O')bis(propan-2-olato) titanium is non sensiting to skin based on the weight of evidence of two read across values.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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