Registration Dossier
Registration Dossier
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EC number: 931-285-8 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The reliability is rated 1 because the study followed a standard guideline, which describes a procedure designed to evaluate this endpoint, the results were reviewed for reliability and assessed as valid, and the study was conducted under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- light catalytically cracked naphtha
- IUPAC Name:
- light catalytically cracked naphtha
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Measured concentrations may not represent 100% of components, remaining hydrocarbon
components in WAFs may be equally toxic and should have been quantitated to determine
total measured concentrations.
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
Test conditions
- Nominal and measured concentrations:
- The mean measured concentrations for nominal loading rates of 0.38, 0.99, 2.6, 6.4, 16,
and 40 mg/l were 0.007, 0.022, 0.11, 0.27, 0.68, and 3.1 mg/l representing the average of
total analytes measured in the new and old WAFs.
The average total analyte concentration in the controls was 0.004 mg/l.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 21 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 16 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
- Duration:
- 21 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 2.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Reported statistics and error estimates:
- For NOEL Fisher's Exact Test was used for survival of adult daphnids and Kruskal-
Wallis Test with Dunn's Multiple Comparison was used for reproduction.
For EL50, survival data were analyzed using the Spearman-Karber method and
reproduction data were analyzed by linear interpolation. TOXSTAT program was used to
determine the endpoints.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Water accommodated fractions of light catalytically cracked naphtha produced a 21 -day
NOELR (No Observed Effect Loading Rate) value of 2.6 mg/L based on reproduction with
Daphnia magna. - Executive summary:
Water accommodated fractions of light catalytically cracked naphtha produced a 21 -day
NOELR (No Observed Effect Loading Rate) value of 2.6 mg/L based on reproduction with
Daphnia magna.
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