4-methoxybenzyl alcohol

Endpoint summary

Description of key information

Appearance/physical state/colour :

Physical appearence of test chemical is observed as colourless organic liquid.

Melting point/freezing point :

Melting point study need not to be conducted as the appearance of test chemical is liquid. Hence this testing was considered waived.

Boiling Point: The boiling point determination of test chemical was done as per the test guideline OECD 103. The method followed was according toSiwoloboff. The boiling point was determined to be greater than 240 °C at 976.8 hPa.

Density:

The density of test chemical was determined following standerd test guideline OECD 109 according to pycnometer method. The density of the test substance was determined to be1.109 g/cm³at 26°C and 965.3 hPa.

Particle size distribution (Granulometry) :

Granulometry (particle size distribution) is a property that is relevant only to solids. Since test chemical is liquid substance this testing was not scientifically possible and hence this end point was waived.

Vapour pressure :

Vapour pressure of test chemical is estimated to be 0.0018 mmHg at 25 degC by means of Modified Grain Method.

Partition coefficient

Based on the available data from study report, the partition Coefficient n-octanol/water of test chemical was determined by Shake Flask Method. The study was performed at a temperature of 27°C and pH 4.57, respectively. The log Pow value of test chemical was determined to be -0.08 dimensiomless at a temperature of 27°C and pH 4.57, respectively. On the basis of this value, test chemical can be considered to be hydrophilic in nature.

Water solubility :

The water solubility determination of test chemical was done as per the shake flask method. The solubility was determined to be greater than 10000 mg/l at 28 degree C.This value suggest that the chemical is very soluble in water.

Surface tension :

Surface Tension of test chemical is estimated as 38.7 ± 3.0 dyne/cm by using Algorithm Version: v12.1.0.50375

Flash point :

The flash point determination of test chemical was done by closed cup method using Pensky Martin’s Flash Point Apparatus. The flashpoint of the test chemical was determined to be 76 °C at 977.8 hPa.

Auto flammability :

Test chemical did not catch fire on being exposed to air at room temperature of 27°C pressure of 966 hPa. This indicates that Test chemical is not auto-flammable.

Flammability :

Flammability is defined as how easily something will burn or ignite, causing fire or combustion in contact with an ignition source. Test chemical was determined to be non flammable when an igntition source having temperature of around 950 degC was brought in close contact with it. Thus it can be concluded that it is a non flammable liquid .

Explosiveness :

In accordance with coulumn 2 of Annex VII, the testing was waived as there are no chemical groups associated with explosive properties in chemical under test.

Oxidising properties

According to redox titration considerations, test chemical possess oxidising properties as end point of the redox titration was obtained at 112.8mg/100g.

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Stability in organic solvents and identity of relevant degradation products :

Using the principle of changes in mass Spectra after dissolving in solvents, the test chemicalis considered to be stable in nature.

Additional information

Appearance/physical state/colour :

Physical appearence of test chemical is observed as colourless organic liquid.

The data obtained from reliable handbook sources indicates that test chemical is observed as an organic colourless liquid with floral odour.

Melting point/freezing point :

Melting point study need not to be conducted as the appearance of test chemical is liquid. Hence this testing was considered waived.

Boiling Point:

The boiling point determination of test chemical was done as per the test guideline OECD 103. The method followed was according toSiwoloboff. The boiling point was determined to be greater than 240 °C at 976.8 hPa.

From other experimental report, the boiling point of test chemical was observed to be 255.3 degC at 966 hpa.

From other reliable resources like handbook and authoritative database, the boiling point of test chemical was observed to be in the range of 257-259°C at 760 mmHg.

Density :

The density of test chemical was determined following standerd test guideline OECD 109 according to pycnometer method. The density of the test substance was determined to be1.109 g/cm³at 26°C and 965.3 hPa.

From other experimental study report, density of test chemical was determined to be 0.988 g/cm3 at temperature 27 °C .

Also from other reliable source,density of test chemical isobserved to be 1.113 g/cm3 at 15°C which is close to the key value.

Particle size distribution (Granulometry) :

Granulometry (particle size distribution) is a property that is relevant only to solids. Since test chemical is liquid substance this testing was not scientifically possible and hence this end point was waived.

Vapour pressure :

Vapour pressure of test chemical is estimated to be 0.0018 mmHg at 25 degC by means of Modified Grain Method.

Partition coefficient

Based on the available data in a key study from study report, the partition Coefficient n-octanol/water of test chemical was determined by Shake Flask Method. The study was performed at a temperature of 27°C and pH 4.57, respectively. The log Pow value of test chemical was determined to be -0.08 dimensiomless at a temperature of 27°C and pH 4.57, respectively.

Additional study from peer reviewed journal, handbook, authoritative and modelling databases,the octanol waterpartition coefficient (log Pow) value of the test chemical was determined to be 1.1.

Thus, based on the available information, the logPow value of the test chemical was determined to be ranges from -0.08 to 1.1, respectively. On the basis of this value, test chemical can be considered to be hydrophilic in nature.

Water solubility :

The water solubility determination of test chemical was done as per the shake flask method. The solubility was determined to be greater than 10000 mg/l at 28 degree C.This value suggest that the chemical is very soluble in water.

From other experimental study report, it is observed that the test chemical is vary soluble in water as its solubility in water was determined ti be 20000 mg/L at 27 degree C, which supports the key value.

Surface tension :

Surface Tension of test chemical is estimated as 38.7 ± 3.0 dyne/cm by using Algorithm Version: v12.1.0.50375.

Flash point :

The flash point determination of test chemical was done by closed cup method using Pensky Martin’s Flash Point Apparatus. The flashpoint of the test chemical was determined to be 76 °C at 977.8 hPa.

Auto flammability :

Test chemical did not catch fire on being exposed to air at room temperature of 27°C pressure of 966 hPa. This indicates that Test chemical is not auto-flammable.

Flammability :

Flammability is defined as how easily something will burn or ignite, causing fire or combustion in contact with an ignition source. Test chemical was determined to be non flammable when an igntition source having temperature of around 950 degC was brought in close contact with it. Thus it can be concluded that it is a non flammable liquid .

Explosiveness :

In accordance with coulumn 2 of Annex VII, the testing was waived as there are no chemical groups associated with explosive properties in chemical under test.

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Oxidising properties

According to redox titration considerations, test chemical possess oxidising properties as end point of the redox titration was obtained at 112.8mg/100g.

Stability in organic solvents and identity of relevant degradation products :

Using the principle of changes in mass Spectra after dissolving in solvents, the test chemicalis considered to be stable in nature.

Dissociation constant :

4-methoxybenzyl alcohol was found to be a weakly dissociating liquid with the pKa value of 0.301 x 10-9, 0.311 x 10-9 , 0.307 x 10-9 obtained

at 27 degrees C.

Viscosity :

The static viscosity of 4 -methoxybenzyl alcohol was found to be 25.68 centistokes (mm²/s) at 27 degC. The viscosity value at 20 degC works out to be 19.02 mm²/s.