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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Method:BASF-Test
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
110-87-2
IUPAC Name:
110-87-2

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
CMC (carboxymethyl cellulose)
Remarks:
0.5% aqueous carboxymethyl cellulose preparation v/v
Doses:
4640, 6810, and 10000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
ca. 4 600 mg/kg bw
Mortality:
10000 and 6810 mg/kg bw: all animlals died
4640 mg/kg bw: 6/10 animals died
Clinical signs:
other: Staggering; signs of paresis; narcotic-like state with absence of pain reflex and corneal reflex
Gross pathology:
Animals that died:
heart: acute dilatation; acute passive hyperemia;
stomach: malacia of the mucosa
intestines: atonic and diarrheal contents
liver: peripheral clay-colored acinar pattern (degeneration) in some cases
thorax: hydrothorax sporadically

Sacrificed animals:
Stomach: adhesions of the stomach to the peritoneum; mucosa of the forestomach thickened

Any other information on results incl. tables

Dose µl/kg

Conc. [%]

Animal No.

Animals died within

1 hour

24 hours

48 hours

7 days

14 days

10000

50

5 male

5/5

5/5

5/5

5/5

5/5

5 female

5/5

5/5

5/5

5/5

5/5

6810

50

5 male

5/5

5/5

5/5

5/5

5/5

5 female

4/5

4/5

5/5

5/5

5/5

4640

46.4

5 male

0/5

2/5

3/5

4/5

4/5

5 female

0/5

1/5

2/5

2/5

2/5

Applicant's summary and conclusion

Conclusions:
Based on the available data, the acute oral LD50 was determined to be 4600 mg/kg bw.
Executive summary:

After a single oral dose administered to rats the calculated LD50 value of 3,4-dihydropyran was 4600 mg/kg bw.