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Diss Factsheets
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EC number: 203-383-4 | CAS number: 106-31-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis study data, provided in section 5.1.2 will be used to demonstrate that butyric anhydride in an aqueous environment will undergo almost immediate hydrolysis to butyric acid. Thus, study data from butyric acid or other similar acids will be used to satisfy all required data points in section 6, as water will be present in all of the studies.
Valid experimental data are available for the endpoints 6.1.1 - short-term toxicity to fish, 6.1.3 - Short-term toxicity to aquatic invertebrates, 6.1.5 - toxicity to aquatic algae and cyanobacteria and 6.1.7 - Toxicity to microorganisms.
Short-term-toxicity to fish
For butyric acid, valid data regarding the short-term toxicity to fish are not available. The exposure period in the studies located (only 48 or 24 h) does not comply with recent test guideline requirements. To compensate for this lack of data, information resulting from valeric acid as supporting substance is used as substitute.
Supporting substance valeric acid:
In a valid short-term toxicity fish test similar to OECD TG 203, the LC50 of valeric acid was determined to be 77 mg/L (Geiger, 1985).
Butyric acid:
The LC50 for butyric acid will be calculated on bases of the LC50 for valeric acid (Geiger 1985) using the respective molecular weights (88.11 and 102.13).
LC50 for butyric acid is derived as ca. 66.4 mg/L.
Short-term toxicity to aquatic invertebrates
For butyric acid, valid data regarding the short-term toxicity to aquatic invertebrates are not available. In the studies located, the exposure period is only 24 h or they exhibit methodological deficiencies. Thus, they do not comply with recent test guideline requirements. To compensate for this lack of data, information resulting from isobutyric acid as supporting substance is used as substitute.
Supporting substance isobutyric acid:
in a valid Daphnia acute immobilization test similar to OECD TG 202, the EC50 of isobutyric acid was determined to be 51,25 mg/L (BASF AG, 1989).
Butyric acid:
As molecular weights of butyric acid and isobutyric acid are equal, the EC50 determined for isobutyric acid can be taken unchanged for butyric acid.
EC50 = 51 mg/L
Toxicity to aquatic algae and cyanobacteria
Valid data regarding the toxicity of butyric acid to aquatic algae and cyanobacteria are not available. To compensate for this lack of data, information resulting from isobutyric acid as supporting substance is used as substitute.
Supporting substance isobutyric acid:
In a valid growth inhibition test with green algae similar to OECD TG 201, the EC50 of isobutyric acid was determined to be 45.1 mg/L (BASF AG, 1990).
Butyric acid
As molecular weights of butyric acid and isobutyric acid are equal, the EC50 determined for isobutyric acid can be taken unchanged for butyric acid.
EC50 = 45.1 mg/L
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