Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-361-8 | CAS number: 613-92-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- May, 2010
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: According to the prediction of toxicity delivered by the software Tox Boxes 2.9, Acute Toxicity overview indicates value with moderate/borderline reliability index.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In silico prediction.
Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made
analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert
knowledge of organic chemistry and toxicology. - GLP compliance:
- no
- Test type:
- other: In silico prediction.
Test material
- Reference substance name:
- Benzamide oxime
- EC Number:
- 210-361-8
- EC Name:
- Benzamide oxime
- Cas Number:
- 613-92-3
- Molecular formula:
- C7H8N2O
- IUPAC Name:
- N-hydroxybenzenecarboximidamide
Constituent 1
Test animals
- Species:
- other: rat/mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levelsopen allclose all
- Dose descriptor:
- LD50
- Effect level:
- 170 mg/kg bw
- Remarks on result:
- other: Acute toxicity overview in rat indicates for DL50 value a borderline reliability index.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 690 mg/kg bw
- Remarks on result:
- other: Acute toxicity overview in mouse indicates for DL50 value a moderate reliability index.
Applicant's summary and conclusion
- Interpretation of results:
- other: judged not reliable
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Acute toxicity overview indicates for the oral LD50 value borderline reliability index.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
