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EC number: 910-853-9 | CAS number: 8011-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with Good laboratory Practice and internationally accepted guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- calcium tetracopper(2+) dioxocopperbis(olate) hexahydroxide sulfate
- EC Number:
- 910-853-9
- Cas Number:
- 8011-63-0
- Molecular formula:
- Ca3Cu4H6O22S4.nH2O where n = 1 to 6
- IUPAC Name:
- calcium tetracopper(2+) dioxocopperbis(olate) hexahydroxide sulfate
- Details on test material:
- - Name of test material (as cited in study report): Bordeaux Mixture
- Composition of test material, percentage of components: Not stated.
- Lot/batch No.: 3/0371
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Three young adult male New Zealand white rabbits weighing 2.1 to 2.4 kg were housed individually and acclimatised prior to dosing.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 grams.
- Duration of treatment / exposure:
- Refer to details on study design.
- Observation period (in vivo):
- 21 days.
- Number of animals or in vitro replicates:
- Three.
- Details on study design:
- 0.1 g of the test substance was administered into the conjunctival sac of the right eye of each rabbit and the eyelids held together for one or two seconds before release. Animals were examined for signs of eye irritation after 1, 24, 48 and 72 hours and up to 21 days after administration, and irritation scored according to Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- 24/48/72 h
- Score:
- 2.1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 2
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 3 animals
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 4 days
- Irritant / corrosive response data:
- Bordeaux Mixture caused corneal opacity (up to score 4), iris lesion (up to score 1), conjunctival redness (up to score 2) and conjunctival chemosis (up to score 3) of the eyes in all animals at one or more assessment times. Cornea opacity persisted up to the end of the study (21 days after administration) in one animal.
- Other effects:
- Records of non relevant endpoints for classification such as the area of the cornea affected and conjunctival discharge were also made in the study but these are not presented in this summary, as they are not relevant to the outcome.
Any other information on results incl. tables
Table 1. Summary of individual and mean eye irritation scores according to Draize
Assessment time |
Scores according to Draize for animal number |
|||||||||||
Cornea opacity |
Iris lesion |
Conjunctival redness |
Conjunctival chemosis |
|||||||||
401 |
402 |
403 |
401 |
402 |
403 |
401 |
402 |
403 |
401 |
402 |
403 |
|
1 hour |
0 |
0 |
0 |
1 |
1 |
1 |
1 |
1 |
1 |
0 |
0 |
0 |
24 hours |
1 |
2 |
4 |
1 |
1 |
-c |
2 |
1 |
2 |
1 |
1 |
3 |
48 hours |
1 |
2 |
4 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
1 |
72 hours |
1 |
2 |
-b |
1 |
1 |
-b |
1 |
1 |
-b |
0 |
1 |
-b |
4 days |
- |
1 |
- |
- |
1 |
- |
- |
1 |
- |
- |
0 |
- |
5 days |
1 |
1 |
- |
0 |
0 |
- |
0 |
0 |
- |
0 |
0 |
- |
6 days |
1 |
1 |
- |
0 |
0 |
- |
0 |
0 |
- |
0 |
0 |
- |
7 days |
1 |
1 |
- |
0 |
0 |
- |
0 |
0 |
- |
0 |
0 |
- |
8 days |
1 |
- |
- |
0 |
- |
- |
0 |
- |
- |
0 |
- |
- |
10 days |
- |
1 |
- |
- |
0 |
- |
- |
0 |
- |
- |
0 |
- |
11 days |
1 |
- |
- |
0 |
- |
- |
0 |
- |
- |
0 |
- |
- |
14 days |
- |
1 |
- |
- |
0 |
- |
- |
0 |
- |
- |
0 |
- |
15 days |
0 |
- |
- |
0 |
- |
- |
0 |
- |
- |
0 |
- |
- |
17 days |
- |
1 |
- |
- |
0 |
- |
- |
0 |
- |
- |
0 |
- |
21 days |
- |
1 |
- |
- |
0 |
- |
- |
0 |
- |
- |
0 |
- |
Mean score per animala |
1.0 |
2.0 |
4.0 |
1.0 |
1.0 |
1.0 |
1.3 |
1.0 |
1.5 |
0.7 |
1.0 |
2.0 |
Mean scorea |
2.1 |
1.0 |
1.3 |
1.3 |
||||||||
a Mean scores after 24, 48 and 72 hours (shaded). b Animal sacrificed prior to 72 hour assessment. c Assessment obscured (by corneal opacity). |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Ocular lesions were severe as corneal opacity persisted until the end of the study.
Classification according to Directive 67/548/EEC: Irritant (Xi). R41, Risk of serious damage to eyes.
Classification according to CLP/GHS: Eye Damage 1, H318: Causes serious eye damage. - Executive summary:
A GLP-compliant study was conducted in accordance with the requirements of EU Method B.5 and OECD 405 without significant deviation. Three young adult male New Zealand white rabbits weighing 2.1 to 2.4 kg were housed individually and acclimatised prior to dosing. 0.1 g of Bordeaux Mixture was administered into the conjunctival sac of the right eye of each rabbit and the eyelids held together for one or two seconds before release. Animals were examined for signs of eye irritation after 1, 24, 48 and 72 hours and up to 21 days after administration, and irritation scored according to Draize. Records of non relevant endpoints for classification such as the area of the cornea affected and conjunctival discharge were also made in the study but these are not presented in this summary, as they are not relevant to the outcome.
Bordeaux Mixture caused corneal opacity (up to score 4), iris lesion (up to score 1), conjunctival redness (up to score 2) and conjunctival chemosis (up to score 3) of the eyes in all animals at one or more assessment times. Cornea opacity persisted up to the end of the study (21 days after administration) in one animal. On this basis, Bordeaux Mixture is classified as Eye Damage Category 1, H318: Causes serious eye damage.
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