Registration Dossier
Registration Dossier
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EC number: 203-841-3 | CAS number: 111-17-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
No experimental data are available for dermal and inhalation absorption. Thus, the assessment is based on the physicochemical properties:
molecular weight:178.21g/mol
water solubility:28.3 g/L at 20°C
log Kow: 0.19
Oral absorption
3,3'-Thiobispropanoic acid is completely absorbed after oral administration.
Dermal absorption
The physicochemical properties and the molecular weight are in a range suggestive of absorption via all routes (molecular weight < 500 g/mol, log Kow between -1 and 4).
For chemical safety assessment a dermal absorption rate of 100% is assumed as a worst case default value (same absorption rate as via the oral route).
Inhalation absorption
For chemical safety assessment an inhalation absorption rate of 100% is assumed as a worst case default value in the absence of other data.
Distribution
As a small molecule a wide distribution can be expected. No information on potential target organs are available.
Metabolism
3,3'-Thiobispropanoic acid is metabolised to CO2 to some extent. At low doses, the substance is conjugated (e.g. with glucuronic acid); at high doses the major fraction is not metabolised.
Elimination
3,3'-Thiobispropanoic acid is mainly excreted via the urine (>90%), only to a minor extent as CO2 (approx. 5%).
Bioaccumulation
Based on the log Kow <3 (0.19) and high elimination rates the substance is unlikely to accumulate with the repeated intermittent exposure patterns normally encountered in the workplace.
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