Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 292-564-1 | CAS number: 90640-45-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The method used in the study which permits the measurement of pH and Alkaline reserve to identify chemicals potentially corrosive to the skin and to the eye was described in V.Froment (1993) and JF.Regnier & C. Imbert (1992), respectively.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Amines, N-C16-22-alkyltrimethylenedi-
- EC Number:
- 292-564-1
- EC Name:
- Amines, N-C16-22-alkyltrimethylenedi-
- Cas Number:
- 90640-45-2
- Molecular formula:
- R-NH-(CH2)3-NH2 R = alkyl mainly C16-22-(even numbered)-alkyl
- IUPAC Name:
- Amines, N-C16-22-alkyltrimethylenedi-
- Test material form:
- solid
- Details on test material:
- Chemical registery number : 292-564-1
Chemical name : Amines, N-C16-22-alkyltrimethylenedi-
Based on the qualitative and quantitative information on the composition, the sample used are representative of the boundary composition shared and agree by each registrant.
Constituent 1
Test animals
- Strain:
- not specified
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- other: Physical-chemical index (I) corrected
- Value:
- 12.55
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Irritation / corrosion parameter:
- other: log R corrected
- Value:
- 1.15
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Irritation / corrosion parameter:
- other: pH
- Value:
- 11.4
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Remarks on result:
- positive indication of irritation
Any other information on results incl. tables
Under the test conditions, the aqueous substance shows a basic character demonstrated by a pH of 11.40 for a 100 g/L solution in water, an alkaline reserve of 14.18 (i.e log R = 1,15) and a physicochemical index of 12.55.
Table 1 : Results of neutralization experiments
Replicate | Dinoram 42 100 g/L, mL | HCl 0,5 N, mL | Initial pH | Final pH | Rcorrected | Log (R) corrected | I |
1 | 20 | 14.355 | 11.40 | 7.00 |
14.18
| 1,15 | 12.55 |
2 | 20 | 14.100 | 11.40 | 7.00 | |||
3 | 20 | 13.500 | 11.40 | 7.00 |
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Conclusions:
- The test item can be considered as potentially corrosive to the skin and severely irritant to the eye
- Executive summary:
The acid/alkaline reserve method can be used at first step of stepwise strategy for assessing cutaneous and ocular irritation.
An amount of the test substance is added to distilled water in a beaker. The solution or suspension is maintained for 4 hours with agitation at 37° C. The pH is directly measured and the sample is then titrated with hydrochloric acid until neutrality is obtained. The acidic or alkaline reserve (R) is expressed as the number of grams of pure acid or base necessary to neutralise 100 g of product (%).
A preliminary titration was performed for a preliminary test to allows good conditions for the alkaline reserve (R) determination: 10 mL volume of a 100 g/L solution are neutralised by approximately 95 mL of 0.5 N HCl. Then for a definitive test, the titration were performed three times more in the same conditions.
Under the test conditions, the aqueous test substance shows an basic character demonstrated by a pH of 11.40 for a 100 g/L solution in water, an alkaline reserve of 14.18 (i.e log R = 1,15) and a physicochemical index of 12.55.
According to the method described, as all the criteria are fulfilled, the test item can be considered as potentially corrosive to the skin and severely irritant to the eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.