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EC number: 206-839-0 | CAS number: 381-73-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish
The lethal concentration (LC50) value of difluoroacetic acid in fish (Pimephales promelas) in a 96 hr study on the basis of mortality effect was estimated to be 165.50 mg/L. Based on this prediction it can be inferred that the target chemical is nontoxic to aquatic environment. The BCF value of dodecan-1-ol, ethoxylated reported was not >= 500 as well as the substance was found to be rapidly degradable
No. of studies reviewed for short – term toxicity to fish from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr. No. |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Sources |
1 |
LC50 |
165.50 mg/L |
Mortality |
96 hrs |
Pimephales promelas |
Predicted data from QSAR |
2 |
LC50 |
121.88 mg/L |
Mortality |
96 hrs |
Lepomis macrochirus |
Predicted data from QSAR |
3 |
LC50 |
52695.99 mg/L |
Mortality |
96 hrs |
Fish |
Predicted data from ECOSAR |
4 |
LC50 |
85971.10 mg/L |
Mortality |
96 hrs |
Fish |
Predicted data from ECOSAR |
By applying weight of evidence approach to the test substance difluoroacetic acid, the endpoint value was found to vary between LC50 = 121.88 mg/L to 165.50 mg/L in a 96 hrs. also found 52695.99 mg/L & 52695.99 mg/L at 96 hrs. study on the basis of mortality effect. The BCF value of difluoroacetic acid reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.
Long term toxicity to fish:
Based on the prediction done using ECOSAR version 1.1, the long term toxicity on fish was predicted for test substance . On the basis of effects observed in a static freshwater system, the NOEC value for the test substance is estimated to be4767.749mg/l for fish for 28 days of exposure duration.Since, the test substance is readily biodegradable , it can be concluded that the test chemicalcan be considered as non-toxic to fish at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.
Short-term toxicity to aquatic invertebrates
No. of studies reviewed for short – term toxicity to fish from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr. No. |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Sources |
1 |
LC50 |
235.79 mg/L |
Mortality |
48 hrs |
Daphnia magna |
Predicted data from QSAR |
2 |
LC50 |
21767.93 mg/L |
Mortality |
48 hrs |
Daphnia magna |
Predicted data from ECOSAR |
By applying weight of evidence approach to the test substance difluoroacetic acid, the endpoint value was found to LC50 = 235.79 mg/L & 21767.93 mg/L in a 48 hrs. to 48 hrs. study on the basis of mortality effect. The BCF value of difluoroacetic acid reported was not >= 500 as well as the substance was found to be rapidly degradable
Long term toxicity to aquatic invertebrate:
Based on the prediction done using ECOSAR version 1.1, the long term toxicity on aquatic invertebrate was predicted for test substance . On the basis of effects observed in a static freshwater system, the NOEC value for the test substance is estimated to be1628.246mg/l for aquatic invertebrate for 21 days of exposure duration.Since, the test substance is readily biodegradable , it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.
Toxicity to aquatic algae and cyanobacteria
No. of studies reviewed for short – term toxicity to aquatic algae and cyanobacteria from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr. No. |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Sources |
1 |
NOEC |
106.73 mg/L |
Growth |
72 hrs |
Pseudokirchneriella subcapitata |
Predicted data from QSAR |
2 |
LC50 |
4141.50 mg/L |
--- |
96 hrs |
Green Algae |
Predicted data from ECOSAR |
By applying weight of evidence approach to the test substance difluoroacetic acid, the endpoint value was found to NOEC = 106.73 mg/L at 72 Hrs & LC50 at 4141.50 mg/L in a 96 hrs. at 72 hrs. study on the basis of growth effect. The BCF value of difluoroacetic acid reported was not >= 500 as well as the substance was found to be rapidly degradable
Toxicity to microorganisms
The effective concentration (EC50) value of difluoroacetic acid in microorganism (Tetrahymena pyriformis) in a 48 hr study on the basis of growth effect was estimated to be 101.2192 mg/L.
Plant Toxicity:
The Nominal concentration of Dichloro acetic acid were 0, 10, 30 & 100 mg/L on Myriophyllum spicatum, M. sibiricum, and Lemna gibba. On which the NOEC & LOEC value was found to be on M. spicatum at Day 14 NOEC was 30 & LOEC 100mg/L., for M. sibiricum day 14 the NOEC 10 & LOEC on 30 mg/L and for L. gibba the NOEC on 14 days at 30 mg/L & LOEC was found to be at 100 mg/Lon Frond number.
Additional information
Short-term toxicity to fish
The lethal concentration (LC50) value of difluoroacetic acid in fish (Pimephales promelas) in a 96 hr study on the basis of mortality effect was estimated to be 165.50 mg/L. Based on this prediction it can be inferred that the target chemical is nontoxic to aquatic environment. The BCF value of dodecan-1-ol, ethoxylated reported was not >= 500 as well as the substance was found to be rapidly degradable
No. of studies reviewed for short – term toxicity to fish from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr. No. |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Sources |
1 |
LC50 |
165.50 mg/L |
Mortality |
96 hrs |
Pimephales promelas |
Predicted data from QSAR |
2 |
LC50 |
121.88 mg/L |
Mortality |
96 hrs |
Lepomis macrochirus |
Predicted data from QSAR |
3 |
LC50 |
52695.99 mg/L |
Mortality |
96 hrs |
Fish |
Predicted data from ECOSAR |
4 |
LC50 |
85971.10 mg/L |
Mortality |
96 hrs |
Fish |
Predicted data from ECOSAR |
By applying weight of evidence approach to the test substance difluoroacetic acid, the endpoint value was found to vary between LC50 = 121.88 mg/L to 165.50 mg/L in a 96 hrs. also found 52695.99 mg/L & 52695.99 mg/L at 96 hrs. study on the basis of mortality effect. The BCF value of difluoroacetic acid reported was not >= 500 as well as the substance was found to be rapidly degradable. Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.
Long term toxicity to fish:
Based on the prediction done using ECOSAR version 1.1, the long term toxicity on fish was predicted for test substance . On the basis of effects observed in a static freshwater system, the NOEC value for the test substance is estimated to be4767.749mg/l for fish for 28 days of exposure duration.Since, the test substance is readily biodegradable , it can be concluded that the test chemicalcan be considered as non-toxic to fish at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.
Short-term toxicity to aquatic invertebrates
No. of studies reviewed for short – term toxicity to fish from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr. No. |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Sources |
1 |
LC50 |
235.79 mg/L |
Mortality |
48 hrs |
Daphnia magna |
Predicted data from QSAR |
2 |
LC50 |
21767.93 mg/L |
Mortality |
48 hrs |
Daphnia magna |
Predicted data from ECOSAR |
By applying weight of evidence approach to the test substance difluoroacetic acid, the endpoint value was found to LC50 = 235.79 mg/L & 21767.93 mg/L in a 48 hrs. to 48 hrs. study on the basis of mortality effect. The BCF value of difluoroacetic acid reported was not >= 500 as well as the substance was found to be rapidly degradable
Long term toxicity to aquatic invertebrate:
Based on the prediction done using ECOSAR version 1.1, the long term toxicity on aquatic invertebrate was predicted for test substance . On the basis of effects observed in a static freshwater system, the NOEC value for the test substance is estimated to be1628.246mg/l for aquatic invertebrate for 21 days of exposure duration.Since, the test substance is readily biodegradable , it can be concluded that the test chemical can be considered as non-toxic to aquatic invertebrate at environmentally relevant concentrations and can be considered not-classified as per the CLP classification criteria.
Toxicity to aquatic algae and cyanobacteria
No. of studies reviewed for short – term toxicity to aquatic algae and cyanobacteria from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr. No. |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Sources |
1 |
NOEC |
106.73 mg/L |
Growth |
72 hrs |
Pseudokirchneriella subcapitata |
Predicted data from QSAR |
2 |
LC50 |
4141.50 mg/L |
--- |
96 hrs |
Green Algae |
Predicted data from ECOSAR |
By applying weight of evidence approach to the test substance difluoroacetic acid, the endpoint value was found to NOEC = 106.73 mg/L at 72 Hrs & LC50 at 4141.50 mg/L in a 96 hrs. at 72 hrs. study on the basis of growth effect. The BCF value of difluoroacetic acid reported was not >= 500 as well as the substance was found to be rapidly degradable
Toxicity to microorganisms
The effective concentration (EC50) value of difluoroacetic acid in microorganism (Tetrahymena pyriformis) in a 48 hr study on the basis of growth effect was estimated to be 101.2192 mg/L.
Plant Toxicity:
The Nominal concentration of Dichloro acetic acid were 0, 10, 30 & 100 mg/L on Myriophyllum spicatum, M. sibiricum, and Lemna gibba. On which the NOEC & LOEC value was found to be on M. spicatum at Day 14 NOEC was 30 & LOEC 100mg/L., for M. sibiricum day 14 the NOEC 10 & LOEC on 30 mg/L and for L. gibba the NOEC on 14 days at 30 mg/L & LOEC was found to be at 100 mg/Lon Frond number.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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