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Diss Factsheets
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EC number: 700-978-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented study according OECD 402 guideline and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- trisodium 2-(2-sulfonatoethoxy)ethane-1-sulfonate ethenesulfonate
- EC Number:
- 700-978-5
- Molecular formula:
- C2H3O3S.Na C4H8O7S2Na2
- IUPAC Name:
- trisodium 2-(2-sulfonatoethoxy)ethane-1-sulfonate ethenesulfonate
- Details on test material:
- - Name of test material (as cited in study report): sodium vinylsulphonate VSS
- Analytical purity: 25.4 %
- Impurities (identity and concentrations): water 66.9%, isethionic acid 2.85%, sulphate 0.70%, insolubles in methanol 1.22%
- Purity test date: 11-01-1993
- Lot/batch No.: 2B20AA
- Stability under test conditions: stable for the duration of the study
- Storage condition of test material: 4°C in dark
- Other:
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Harlan Olac Ltd., Bicester, Oxon, England
- Age at study initiation: 7-10 weeks prior to dosing (day 1)
- Weight at study initiation: 200-243 g
- Housing: individually in metal cages with wire mesh floors in building R14 room 6
- Diet (e.g. ad libitum): standard laboratory rodent diet (Biosure LAD1) ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22°C
- Humidity (%): mean daily relative humidity was 49% R.H.
- Air changes (per hr): 10 to 15 air changes per hour
- Photoperiod (hrs dark / hrs light): 12/12, 12 hours artificial light (0700-1900 hours)
IN-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: approximately 50 mm x 50 mm
- Type of wrap if used: gauze which was held in place with a non-irritative dressing encircled firmly around the trunk
REMOVAL OF TEST SUBSTANCE
- Washing (if done):at the end of 24h exposure skin was washed with warm (30 to 40 °C) water and blotted dry with absorbent paper
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 g/kg bw - Duration of exposure:
- 24 h
- Doses:
- 2 g/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: cages of rats were checked at least twice daily for any mortalities, bodyweights were recorded on day 1, 8 and 15. Individual weekly bodyweight changes were calculated.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: animals were observed soon after dosing and at frequent intervals for the remainder of day 1 (a period of 7 h). On subsequent days animals were observed once in the morning and again at the end of the experimental day. This latter observation was at approx 16.30 h on week days or 11.30 h on Saterdays, Sundays abd public holidays. The nature and severity of the clinical signs and time were recorded at each observation.
Macroscopic examination: all animals were killed on Day 15 by cervical dislocation and were subjected to a macroscopic examination which consisted of opening the abdominal and thoracic cavities. The macroscopic appearance of all examined tissues was recorded.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no deaths following a single dermal application of sodium vinylsulphonate at 2000 mg/kg bw.
- Clinical signs:
- other: There were no signs of systemic reaction to treatment.
- Gross pathology:
- No macroscopic abnormalities were observed for animals killed on Day 15.
Applicant's summary and conclusion
- Conclusions:
- The acute lethal dermal dose to rats of sodium vinylsulphonate was found to be greater than 2000 mg/kg bw.
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