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EC number: 805-107-3 | CAS number: 40758-65-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in accordance with generally accepted scientific principles; however full data on methodology is not given and no information relating to GLP status is provided. An accurate assessment of the study is therefore not considered to be possible.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rabbits were exposed to the test material for 24 hours in an occlusive fashion at a single dose level, with two animals per dose.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4,6-Dichloro-2-ethoxypyrimidine
- EC Number:
- 805-107-3
- Cas Number:
- 40758-65-4
- Molecular formula:
- C6H6Cl2N2O
- IUPAC Name:
- 4,6-Dichloro-2-ethoxypyrimidine
- Test material form:
- other: aqueous solution
- Details on test material:
- - Physical state: liquid (20% aqueous solution)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: ~3.8 kg
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The test material was applied to the clipped back.
- Type of wrap if used: The test material was held in contact with the skin with a porous gauze dressing. A plastic wrap was then placed around the gauze and trunk of the rabbit and secured with non-irritating tape. The plastic wrap was covered with flannel bandages and held in place with non-irritating tape.
TEST MATERIAL
- Concentration (if solution): 20 % solution in water. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg )of a 20% aqueous solution)
- No. of animals per sex per dose:
- 2 males
- Control animals:
- no
Results and discussion
- Mortality:
- One animal was euthanised on the day of dosing. The remaining animal was found dead on day 2.
- Clinical signs:
- Within 1 hour after dosing, one rabbit was observed with mouth breathing, convulsions, rolled eyes, bleeding through nose and laboured respiration. The animal was euthanised because of severe convulsions.
The remaining rabbit was observed with mouth breathing, convulsions, laboured respiration and tremors on day one, and was found dead on day 2.
Applicant's summary and conclusion
- Interpretation of results:
- other: it is not possible to assign a classification with available data
- Conclusions:
- The report does not include an LD50 value; however both animals dosed at 2000 mg/kg as a 20 % aqueous solution died. At least Category 3 classification under CLP is required, based on a calculated LD50 in terms of neat substance of <400 mg/kg.
- Executive summary:
The acute toxicity potential of the test material was investigated via the dermal route.
Two male rabbits received a single dermal application of 2000 mg/kg which was administered as a 20 % solution in water. The test material was applied to the clipped back and held in contact with the skin in an occlusive fashion.
Within 1 hour after dosing, one rabbit was observed with mouth breathing, convulsions, rolled eyes, bleeding through nose and laboured respiration. The animal was euthanised because of severe convulsions. The remaining rabbit was observed with mouth breathing, convulsions, laboured respiration and tremors on day one, and was found dead on day 2.
The report does not include an LD50 value but this can be calculated at <400 mg/kg based on neat substance.
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