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Diss Factsheets
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EC number: 216-378-7 | CAS number: 1569-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a test protocol that is comparable to the appropriate OECD test guideline. It was not compliant with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Cyclohexanethiol
- EC Number:
- 216-378-7
- EC Name:
- Cyclohexanethiol
- Cas Number:
- 1569-69-3
- Molecular formula:
- C6H12S
- IUPAC Name:
- cyclohexanethiol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material: Cyclohexyl Mercaptan
No other information reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 100 to 118 g
- Fasting period before study: 16 to 24 hours before dosing
- Housing: Standard laboratory rat stock cages
- Diet: ad libitum(except before dosing, see above)
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% w/v - Doses:
- 0.900, 1.350, 2.025, 3.038 g/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes - Statistics:
- Acute oral mean lethal dose (LD50) was calculated using tables contructed by Weil (based on formulae presented by Thompson and Weil and involving moving averages and interpolation as developed by Thompson).
Thompson, William R and Weil, Carrol S.: On the Construction of Tables for Moving Average Interpolation. Biometrics, March 1952
Thompson, William R.: Use of Moving Averages and Interpolation to Estimate Median-Effective Dose. Bact. Rev., Nov. 1947
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1.22 other: g/kg
- Based on:
- test mat.
- Mortality:
- All animals at 3.038 or 2.025 g/kg died from 5.5 hours to 12 days after dose administration. One male and 1 female at 1.350 g/kg died 4 days after dosing.
There were no deaths in 0.900 g/kg animals. - Clinical signs:
- other: Lethargy and/or generalised weakness and diarrhea were noted at all doses from immediately after dosing up to Day 7.
- Gross pathology:
- Hyperemic lungs, intestinal mucosa and pyloric region of stomach, together with prescence of blood in the gastro-intestinal tract, were noted in rats at all doses except 0.900 g/kg.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity study rats, following a protocol that is similar to the now-deleted OECD 401 test guideline, the LD50was calculated to be 1.22 g/kg +/- 0.12 g/kg.
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