Registration Dossier
Registration Dossier
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EC number: 700-308-1 | CAS number: 1335203-19-4
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Long-term toxicity testing in fish is not necessary since there are sufficient chronic toxicity data in invertebrates (e. g., Daphnia magna) to indicate that the substance, "reaction products of 1-decene, 1-dodecene, and 1-octene, hydrogenated", is unlikely to cause long-term aquatic toxicity at its maximum water solubility limits. Other supporting data indicate that the test substance is not acutely toxic to fish, invertebrates and algae at it maximum water solubility limits.
Further, the test substance is not persistent or bioaccumulative (see Section 4). As pointed out on page 54 of the 2008 ECHA-REACH Guidance on Information Requirement and Chemical Safety Assessment, Chapter R.7b: “PBT assessment: chronic fish toxicity testing is generally only necessary, when the P and B criteria are fulfilled. ” Since the test substance, "reaction products of 1-decene, 1-dodecene, and 1-octene, hydrogenated", does not fulfill the P and B criteria, chronic fish toxicity testing is not necessary.
Key value for chemical safety assessment
Additional information
Chronic fish toxicity data were not available to directly evaluate the long-term toxicity to fish for the reaction products of 1-decene, 1-dodecene and 1-octene, hydrogenated. However, there are sufficient read-across chronic toxicity data inDaphnia magna(Section 7.1.1.2.2) to help assess the long-term toxicity potential in fish. Mitigating factors include the fact that the registered substance is very insoluble in water and that it is not acutely toxic to fish, daphnids or algae (see tables). Collectively, these data indicate that the reaction products of 1-decene, 1-dodecene, and 1-octene, hydrogenated would not be expected to cause long-term toxicity to fish. Consistent with Annex IX, there does not appear to be a need to further conduct long-term toxicity testing in fish, given the lack of acute toxicity observed in fish, daphnids and algae (at the maximum water solubility limits) and the lack of chronic toxicity reported inDaphnia magnaas well as the insoluble nature of the substance.
Furthermore, the reaction products of 1-decene, 1-dodecene, and 1-octene, hydrogenated are not persistent and not bioaccumulative (see Section 4). As pointed out on page 54 of the ECHA Guidance on Information Requirement and Chemical Safety Assessment, Chapter R.7b (ECHA 2008d): “PBT assessment: chronic fish toxicity testing is generally only necessary, when the P and B criteria are fulfilled.” Since the reaction products of 1-decene, 1-dodecene, and 1-octene, hydrogenated, do not fulfill the P and B criteria, chronic fish toxicity testing is not necessary (i.e., data waiving).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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