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EC number: 238-122-3 | CAS number: 14246-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-(1-oxooctyl)glycine
- EC Number:
- 238-122-3
- EC Name:
- N-(1-oxooctyl)glycine
- Cas Number:
- 14246-53-8
- Molecular formula:
- C10H19NO3
- IUPAC Name:
- N-(1-oxooctyl)glycine
- Details on test material:
- - Name of test material (as cited in study report): LCA07012
- Substance type: mono-constituant
- Physical state: solid
- Analytical purity: >97%
- Lot/batch No.: 716300006
- Expiration date of the lot/batch: 11.06.2010
- Stability under test conditions: yes
- Storage condition of test material: room temperature (20 ± 5 °C)
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: 105-110°C
- Vapour pressure: 1.33*10-4Pa
- log Pow: 2.052 ± 0.023
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- none
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
Test System HPLC DIONEX with UV-Detector, DIONEX
Column: Reprosil 100 C18 4.6*150mm (Dr.Maisch)
Mobile phase: mixture of 50 % CH3CN, 50 % H2O (pH 2.0)
Flow rate: 1 mL/min.
Column temperature: 25 °C
Detection λ: 200 nm
Injection volume: 20 µL
Retention Time Test Item: 3.1 – 3.8 min.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: danio rerio
- Strain: HAMILTON-BUCHANAN
- Age at study initiation (mean and range, SD): sexually immature young fish, length 2.1 cm
temperature: 23.5°C
ACCLIMATION
- Acclimation period:14 days
- Acclimation conditions (same as test or not):same as the study
- Type and amount of food:warmwater fishfood and daphnia
- Feeding frequency: three times a day with warmwater fishfood and daphnia, totalling to about 1-2% of body weight per day
- Health during acclimation (any mortality observed):the mortality not surpassing 5%
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- mortality
Test conditions
- Hardness:
- 24 hours before the start of the test, food was withheld from the designated test fish.
Medium renewal every 24 ± 1 hours
Duration 96 hours
Loading 1 fish/L
Vessels: glass aquaria, maximal volume 10 L
Aeration: accomplished with glass tubes, frequency of bubbles 1/s
Feeding: none
Photo period: 12/12 hours using neon tubes
Temperature: 23 ± 1 oC
pH adjustment: none
Replicates: one vessel for each treatment and for the control
Observations were made every 24 hours, measuring pH and O2-concentration of the old and new test solution in each vessel and documentating mortalities or abnormal behav-iour. In the main study the content of the test item in the test vessels was measured at every medium renewal in the old and the new test solutions.
A fish was considered dead, if no visible movement could be observed, and if touching of the caudal peduncle produced no reaction. - Test temperature:
- Temperature range was 20.3 – 20.4 °C.
Nominal Concentration in mg/L pH at t in h (old/new test solution)
0 h 24 h 48 h 72 h 96 h
new old new old new old new old
0 8,1 8,0 8,4 7,9 8,2 7,8 8,1 7,8
100 7,0 7,9 7,1 7,8 7,9 7,4 7,9 7,4 - pH:
- 7.0 to 8.4.
- Dissolved oxygen:
- Nominal Concentration in mg/L O2 in mg/L at t in h (old/new test solution)
0 h 24 h 48 h 72 h 96 h
new old new old new old new old
0 9.0 8.0 8.8 8,0 9,2 8,1 9,0 9,8
100 8,8 8,1 8,4 7,9 9,1 6,7 9,3 8,4
. The concentration of dissolved oxygen stayed above 8.4 mg/L or 93 % throughout the test
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
Any other information on results incl. tables
- Sublethal observations / clinical signs:
The biological results are presented in the following table:
Biological Results
Parameter
Value
95%-confidence-interval
24h NOEC
100 mg/L
not determinable
24h LC50
> 100 mg/L
not determinable
24h LC100
>> 100 mg/L
not determinable
48h NOEC
100 mg/L
not determinable
48h LC50
> 100 mg/L
not determinable
48h LC100
>> 100 mg/L
not determinable
72h NOEC
100 mg/L
not determinable
72h LC50
> 100 mg/L
not determinable
72h LC100
>> 100 mg/L
not determinable
96h NOEC
100 mg/L
not determinable
96h LC50
> 100 mg/L
not determinable
96h LC100
>> 100 mg/L
not determinable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- • The mortality in the control may not exceed 1 fish at the end of the test.
No mortalities occurred in the control.
• The dissolved oxygen concentration must be at least 60% throughout the test.
The concentration of dissolved oxygen stayed above 6.9 mg/L or 81 % throughout the test (100 % at 101300 Pa equals 8.57 mg/L, following DIN 38408 part 22).
• The pH-value in the test solutions should not vary more than 1 unit during the test.
The highest variation was 0.9 units. - Executive summary:
In a pre-test, the concetrations 100; 10 and 1 mg/L were tested in a static performance. For each concentration, three fish were exposed to the test item for 96 hours.
The main study was performed as a limit test using a nominal concentration of 100 mg/L in a semi static test with medium renewal every 24 hours.
No mortality was observed in the treatment and the control, no fish showed any signs of morbidity at the end of the test. The pH and the oxygen values of the water were normal.
At every medium renewal, the content of the test item in the old and the new test solutions was determined using HPLC. The recovery after 24 hours lay in a range between 93 and 102 % of the start concentration and the correlation between nominal and measured concentration was very good (100 – 112 %). Therefore, the determination of the results was based on the nominal concentration.
The following results for the test itemLCA07012could be determined:
96h NOEC = 100 mg/L
96h LC50 > 100 mg/L
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