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EC number: 428-420-3 | CAS number: 71119-22-7 MOPS-NA
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- not specified
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.6 (GPMT)
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- No LLNA study was conducted as an in vivo study according was available before the first version of the LLNA (OECD 429) was issued in 2002.
Test material
- Reference substance name:
- Sodium 3-morpholin-4-ylpropane-1-sulfonate
- EC Number:
- 428-420-3
- EC Name:
- Sodium 3-morpholin-4-ylpropane-1-sulfonate
- Cas Number:
- 71119-22-7
- Molecular formula:
- C7H14NNaO4S
- IUPAC Name:
- sodium 3-(morpholin-4-yl)propane-1-sulfonate
- Test material form:
- solid: particulate/powder
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No further information provided in SNIF.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- intradermal
- Vehicle:
- other: distilled water and distilled water with Freuds adjuvance (1:1)
- Concentration / amount:
- 5 %
- Route:
- epicutaneous, open
- Vehicle:
- water
- Concentration / amount:
- 50 %
Challenge
- No.:
- #1
- Route:
- other: No further information provided in SNIF.
- Vehicle:
- water
- Concentration / amount:
- 25 and 50 %
- No. of animals per dose:
- 10 animals in test group and 5 in negative control group
- Details on study design:
- Pretreatment for topical induction exposure: 10 % w/v sodium-dodecyl-sulfate was applied.
No further information provided in SNIF. - Challenge controls:
- No further information provided in SNIF.
- Positive control substance(s):
- no
Results and discussion
- Positive control results:
- Not conducted.
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 25 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 50 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 25 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 50 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 25 %
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 50 %
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 25 %
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 50 %
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Group:
- positive control
- Remarks on result:
- other: No positive control was conducted.
Any other information on results incl. tables
SKIN REACTIONS OBSERVED AFTER INTRADERMAL INDUCTION:
Well-defined or moderate to severe erythema was noted at the intradermal induction sites of all test group animals at the 24-hour observation with very slight erythema a the 48-hour observation.
Very slight erythema was noted at the intradermal induction sites of three control animals at the 24-hour observation.
No skin reaction were noted at the intradermal induction sites of control group animals at the 48-hour observation.
SKIN REAKTIONS OBSERVED AFTER TOPCAL INDUCTION:
Very slight to well-defined erythema and very slight oedema were noted at the induction sites of all test group animals at the 1-hour observation.
Very slight erythema was noted at the induction sites of 4 test group animals at the 24-hour observation.
Other skin reactions noted in test group animals were bleeding from injection sites and desquamation.
Very slight to well-defined erythema and very slight oedema were noted at the treatment sites of all control group animals at the 1-hour observation.
Very slight erythema, with or without very slight oedema, was noted at the treatment sites of 4 control group animals at the 24-hour observation.
Other skin reactions noted in control group animals were bleeding from injection sites and desquamation.
Other observations:
Bodyweight gains of animals in the test group, between day 0 and day 24, were comparable to those observed in the control group animals over the same period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item showed no skin senitisation potential in an in vivo study in guinea pigs.
- Executive summary:
A study was performed to assess the skin sensitisation potential of the test material using guinea pigs. The method used followed the recommendations of 92/69/EWG, B.6 (GPMT). Intradermal induction was done with 5 % test material in distilled water and distilled water with Freuds adjuvant (1:1). A topical induction with 50 % test item concentration was done. The challenge was performed with test item concentrations of 25 and 50 %. For each test item treatment group 10 animals were used. Furthermore, negative control groups were included with each 5 animals. After inductions slight erythema and oedema were observed in animals treated with the test item or the negative control. Both at the first and second reading after the challenge no positive reactions were observed in any of the test item treated animals or control animals, independent of the concentration. The test material is therefore considered to be no skin sensitizer.
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