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EC number: 212-414-0 | CAS number: 814-94-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Tin(II) oxalate
- EC Number:
- 212-414-0
- EC Name:
- Tin(II) oxalate
- Cas Number:
- 814-94-8
- Molecular formula:
- C2H2O4.Sn
- IUPAC Name:
- tin(II) oxalate
- Details on test material:
- - Name of test material (as cited in study report):Tin (II) Oxalate - Molecular formula (if other than submission substance):C2H2O4.Sn- Molecular weight (if other than submission substance):206.7096- Substance type: Organometallic- Physical state: Solid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS- Age at study initiation:10 to 12 weeks- Weight at study initiation:2.0kg ±200g- Housing:Rabbit was housed in stainless steel cages provided with stainless steel mesh bottom and facilities for food and water bottle.- Diet (e.g. ad libitum):Pelleted feed supplied ad libitum- Water (e.g. ad libitum):Community tap water passed through ‘Aqua Guard on line water filter’ was kept in bottles, ad libitum.- Acclimation period:The rabbit was acclimatized to standard laboratory condition for 24 hours in experimental room before study.ENVIRONMENTAL CONDITIONS- Temperature (°C):22-25 deg.C- Humidity (%):40-60% - Air changes (per hr):10-15 air changes per hour- Photoperiod (hrs dark / hrs light):illumination cycle set to 12 hours artificial fluorescent light and 12 hours dark..
Test system
- Vehicle:
- other: distilled water
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL- Amount(s) applied (volume or weight with unit):0.1 gm
- Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- 21 days.
- Number of animals or in vitro replicates:
- Three
- Details on study design:
- REMOVAL OF TEST SUBSTANCE- Washing (if done):after 24 hrs.- Time after start of exposure:1, 24, 48 and 72 hours SCORING SYSTEM:Draize et al.TOOL USED TO ASSESS SCORE: biomicroscope and hand slit lamp further examined with the aid of fluorescein.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hrs.
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- other: Tin (II) Oxalate is practically non-irritant to the eyes of New Zealand white rabbit at the dose level of 0.1g under test condition.
- Irritant / corrosive response data:
- The test compound Tin (II) Oxalate (CAS No.-814-94-8) when applied to the eye of New Zealand white rabbit at the dose level of 0.1 gm did not produce any eye irritation throughout the observation period of 72 hours. After that the animals were observed for 21 days for any eye irritation and eye discharge.
- Other effects:
- Clinical Signs:The test compound Tin (II) Oxalate (CAS No.-814-94-8) applied in conjunctival sac of rabbits did not show any observable clinical signs throughout the observation period of 21 days.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- Based on the result obtained from present study, it can be concluded that the test compound Tin (II) Oxalate (CAS No.-814-94-8) is practically non-irritant to the eyes of New Zealand white rabbit at the dose level of 0.1g under test condition.
- Executive summary:
Theacute eye irritation study ofTin (II) Oxalate (CAS No.-814-94-8) was conducted in New Zealand White Rabbits as per the OECD- 405 Guideline for testing of chemicals. The study was conducted stepwise as follows-
Initial test (using one animal):
One healthy rabbits of body weight 2.13Kg was selected for study after acclimatization. Rabbit was examined for any abnormal discharge such as eye irritation, ocular defects or pre-existing corneal injury from eye 24 hours prior to application of test compound.
The test compound was applied in the conjunctival sac of rabbit after gently pulling the lower lid away from the eyeball at the dose rate of0.1gm.The other eye which remain untreated, served as a control. The acute irritation to eye conjunctiva, cornea and iris was evaluated at 1, 24, 48 and 72 hoursafter the treatment. The grades of ocular reaction (conjunctiva, cornea and iris) were recorded at each observation. To determine the reversibility of the effect the animal was observed normally for 21 days. Any other lesions in the eye viz pannus, staining were observed and scored accordingly. Examination of reactions was facilitated by use of biomicroscope and hand slit lamp. Individual animal weight before and during the study was observed.
The test compound Tin (II) Oxalate (CAS No.-814-94-8) when applied to conjunctival sac of rabbit in the amount of0.1gmdid not produce any eye irritation or inflammation. Furthermore, no other clinical signs were recorded after application of test compound such as cage side activity, pain etc.
Confirmatory test (using two additional animals):
The result obtained from the initial test was confirmed in additional two animal of same sex and same dose level (OECD-405, paragraph-21).
In the confirmatory test the test compound was applied in the amount of 0.1 gm in the conjunctival sac of rabbit after gently pulling the lower lid away from the eyeball. The other eye which remain untreated, served as a control. The acute irritation to eye conjunctiva, cornea and iris was evaluated at 1, 24, 48 and 72 hoursafter the treatment. The grades of ocular reaction (conjunctiva, cornea and iris) were recorded at each observation. To determine the reversibility of the effect the animals were observed normally for 21 days. Any other lesions in the eye viz pannus, staining were observed and scored accordingly. Examination of reactions was facilitated by use of biomicroscope and hand slit lamp. Individual animal weight before and during the study was observed.
In the confirmatory test, the test compound Tin (II) Oxalate (CAS No.-814-94-8) when applied to the conjunctival sac of the rabbits did not produce eye irritation during the entire observation period. However, some blood vessels observed hyperemic upto 24 hours after the application of test compound. There were no other signs observed throughout the observation period of 21 days.
Based on above findings, it can be concluded that the test compound Tin (II) Oxalate (CAS No.-814-94-8) is practically non-irritant at the tested dose level 0.1 mg under test condition.
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