Lithium naphthalene-2-carboxylate

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

21 May 2008 and 02 June 2008

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2008

Report date:

2008

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

The work described was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Lithium naphthalene-2-carboxylate

EC Number:

700-040-5

Cas Number:

674347-28-5

Molecular formula:

C11 H7 Li O2

IUPAC Name:

Lithium naphthalene-2-carboxylate

Results and discussion

Water solubility

Water solubility:

44.7 g/L

Temp.:

20 °C

pH:

ca. 7.6

Any other information on results incl. tables

  Results

         Preliminary test

Observations, concentrations and pH relating to the samples are shown in the following table:

Sample	Concentration (% w/w)	Observation	pH
1	1.0	Clear, colourless solution, with no excess, undissolved test material.	7.2
2	5.0	Clear, peach-coloured solution, with a slight excess of undissolved test material.	7.9
3	10.0	As for Sample 2, but more excess undissolved test material.	8.0
4	15.0	As for Sample 3, but more excess undissolved test material.	8.0
5	20.0	As for Sample 4, but more excess undissolved test material.	8.1
6	26.0	Much excess undissolved test material.	8.2

The preliminary estimate of water solubility was between 1.0 and 5.0 % w/w of solution.

            Definitive test

The absorbances relating to the standard and sample solutions are shown in the following table:

Solution	Absorbance
Standard 26.0 mg/l	0.90176
Standard 25.6 mg/l	0.85456
Matrix blank	None detected
Sample 1A	0.60598
Sample 1B	0.60448
Sample 2A	0.61680
Sample 2B	0.61065
Sample 3A	0.60404
Sample 3B	0.60876

The concentration (g/l) of test material in the sample solutions is shown in the following table:

Sample Number	Time Shaken at ~ 30ºC (hours)	Time Equilibrated at 20ºC (hours)	Concentration (g/l)	Solution pH
1	24	24	44.4	7.7
2	48	24	45.1	7.6
3	72	24	44.5	7.6

Mean concentration:     44.7 g/l at 20.0 ± 0.5ºC
Range:                          44.4 to 45.1 g/l

Validation

The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 50 mg/l.  This was satisfactory with a correlation coefficient of 1.00 being obtained.

Conclusion

The water solubility of the test material has been determined to be 44.7 g/l of solution at 20.0 ± 0.5°C.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The water solubility of the test material has been determined to be 44.7 g/l of solution at 20.0 ± 0.5°C.

Executive summary:

The determination was carried out using the flask method, Method A6 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC).

The water solubility of the test material has been determined to be 44.7 g/l of solution at 20.0 ± 0.5°C.