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Diss Factsheets
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EC number: 209-128-3 | CAS number: 556-52-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not documented
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicology of glycidol and glycidyl ethers
- Author:
- Hine, C.H. et al.
- Year:
- 1 956
- Bibliographic source:
- Arch. Ind. Health 14, 250-264 (1956)
- Report date:
- 1956
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test was conducted in male rabbits and scored using the Draize method
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,3-epoxypropan-1-ol
- EC Number:
- 209-128-3
- EC Name:
- 2,3-epoxypropan-1-ol
- Cas Number:
- 556-52-5
- Molecular formula:
- C3H6O2
- IUPAC Name:
- (oxiran-2-yl)methanol
- Details on test material:
- - Name of test material (as cited in study report): Glycidol
- Molecular weight (if other than submission substance): 74.05
- Physical state: Liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: California albino or New Zealand white
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Point Reyes, California or Gilroy Laboratory, California.
- Age at study initiation: Not documented
- Weight at study initiation: 2 - 3kg
- Housing: Not documented
- Diet (e.g. ad libitum): Not documented
- Water (e.g. ad libitum): Not documented
- Acclimation period: Not documented
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not documented
- Humidity (%): Not documented
- Air changes (per hr): Not documented
- Photoperiod (hrs dark / hrs light): Not documented
IN-LIFE DATES: From: To: Not documented
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- 100 µL
- Duration of treatment / exposure:
- 48 hours
- Observation period (in vivo):
- 48 hours. Readings were made at 1, 24 and 48 hours after treatment.
- Number of animals or in vitro replicates:
- Not documented
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not documented
- Time after start of exposure: Not relevant
SCORING SYSTEM: Draize method
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Results
- Irritation parameter:
- maximum mean total score (MMTS)
- Basis:
- mean
- Time point:
- other: 1, 24 and 48 h
- Score:
- 68
- Max. score:
- 102
- Reversibility:
- not specified
- Remarks on result:
- other: Score is the average for the 3 readings.
- Irritant / corrosive response data:
- severely irritating
- Other effects:
- No information provided
Any other information on results incl. tables
Average Draize score: 68
No blindness or permanent defects in the cornea, lens, or iris.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information The Kay and Calendra type score was 68 on a scale of 0 -110. Concluded to be a moderate irritant Criteria used for interpretation of results: OECD GHS
- Conclusions:
- In this eye irritation study in rabbits glycidol was severely irritating. However, no blindness or permanent defects in the cornea, lens or iris resulted. Under the conditions of this study, due to the lack of information on the number of animals tested and the individual scores for corneal, iris and conjunctival effects and the reversibility of the effects observed, it was not possible to determine a classification according to Regulation EC no. 1272/2008 or Directive 67/548/EEC. However, the material appears to be a moderate irritant and was assigned a GHS Category 2 (Irritating to eyes) classification and by read acoss to Directive 67/548/EEC was assigned R36 Irritating to eyes.
- Executive summary:
In a study conducted by Hine et al (1956), the test substance, Glycidol, was examined for its ability to cause irritation when applied to the eye of male Californian albino or New Zealand White rabbits. 100ul of the test substance was applied to one eye of each rabbit, with the other serving as the control. Following application, readings were made at 1, 24 and 48 hours post exposure. The mean of these three scores was used to evaluate the effects. In this eye irritation study in rabbits glycidol was severely irritating. However, no blindness or permanent defects in the cornea, lens or iris resulted. Under the conditions of this study, due to the lack of information on the number of animals tested and the individual scores for corneal, iris and conjunctival effects and the reversibility of the effects observed, it was not possible to determine a classification according to Regulation EC no. 1272/2008 or Directive 67/548/EEC.
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