Registration Dossier
Registration Dossier
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EC number: 227-563-7 | CAS number: 5888-87-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, Division of Pharmacology, FDA, Hautgiftigkeit nach Draize (1959)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Vernetzer HC
- IUPAC Name:
- Vernetzer HC
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Vernetzer HC is the former name of BRUGGOLEN® C20.
BRUGGOLEN® C20 is a mixture of 80% N,N'-hexane-1,6-diylbis(hexa-hydro-2-oxo-1H-azepine-1-carboxamide with 20% epsilon-Caprolactam.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 8
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: after 24h and after 72h; mean value is determined
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable, no irritation occured
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: FDA
- Conclusions:
- The test item has not to be classified as "irritant".
- Executive summary:
The test item has not to be classified as "irritant".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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