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Diss Factsheets
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EC number: 432-080-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 February 1999 to 05 February 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L
- Sampling method: direct weighing
- Sampling: Daily analysis of the only test concentration plus a control. - Vehicle:
- no
- Details on test solutions:
- Control: Synthetic fresh water in accordance with ISO
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Species: Zebra fish (Brachydanio rerio HAMILTON BUCHANAN)
Origin: Bio International B.V. (Netherlands)
Date of birth: 09.09.1998
Date supplied: 25.11.1998
Body length: 2.5 – 3.5 cm
Keeping conditions: SOP 2030-7700103-98 D
Mortality while kept: < 2%
Medical pre-treatment: none
Keeping water: Synthetic fresh water in accordance with ISO. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No post observation period
- Hardness:
- 13.5 mg CaCO3/L
- Test temperature:
- 20.8-22.0
- pH:
- 7.7-8.0
- Dissolved oxygen:
- 8.8-9.6 mg/l
- Salinity:
- Not applicable.
- Nominal and measured concentrations:
- 100 mg/l (nominal)
- Details on test conditions:
- Operating conditions: Static test in accordance with study method.
Photoperiod: 16 hours light / 8 hours dark
Test procedure: - test vessels (300 x 135 x 200 mm)
-51 test medium
-ventilated
-static
Method of administration: direct weighing (SOP 2030-6600401-96 D)
Test concentration/s: 100 [mg/1]
Solubilizer or other auxiliaries: none
Control: Synthetic fresh water in accordance with ISO.
Water for dilution: Synthetic fresh water in accordance with ISO. - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 100 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: Equates to >=79.6 mg/l of organic components.
- Details on results:
- The test result refers to a concentration of the test substance, which was calculated directly from analytically determined TOC values. According to the relevant product information, 1 mg/l TOC equals to 2.6 mg/l of the organic components of the test substance.
As these organic components correspond to 73%
of the molecular weight of the test substance 100 mg/l of the test substance equals to 28.1 mg/l organic C.
Thus, the above analytical values indicate a very good recovery rate.
Some test fish had a somewhat smaller size than the one recommended in the test guideline for the zebra fish. Deviating from the preliminary test, a mortality rate of 10% was detected in the main test at the limit test concentration of 100 mg/l. The validity criteria of the above test guideline permit a maximum mortality of 10% in the control.
Considering all test concentrations involved, temperature fluctuation was bigger than 1⁰C in the course of the study. - Results with reference substance (positive control):
- Not applicable.
- Sublethal observations / clinical signs:
Concentration of the test substance: 100 mg/l
Mortality
2h
24h
48h
72h
96h
Absolute
0
0
1
0
0
Cumulative
0
0
1
1
1
Cumulative [%]
0
0
10
10
10
Concentration of the test substance: control
Mortality
2h
24h
48h
72h
96h
Absolute
0
0
0
0
0
Cumulative
0
0
0
0
0
Cumulative [%]
0
0
0
0
0
- Conclusions:
- Exposure time: 96 h
arithmetic mean of analytical values
LC 0: >= 79.6 mg/l - Executive summary:
Study conducted to EU test guidance 92/66/EEC part C.1, in compliance with GLP.
Exposure time: 96 h
arithmetic mean of analytical values
LC 0: >= 79.6 mg/l organic quotient.
LC0 overall: >=100 mg/l
The substance is not considered to be harmful to fish.
Reference
Description of key information
The LC50 was above 100 mg/L after 96 hours. The substance is not considered to be harmful to fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 100 mg/L
Additional information
Study conducted to EU test guidance 92/66/EEC part C.1, in compliance with GLP.
Exposure time: 96 h
arithmetic mean of analytical values
LC0: >= 79.6 mg/L organic quotient.
LC0 overall: >=100 mg/L
The substance is not considered to be harmful to fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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