Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 285-206-0 | CAS number: 85049-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The potential for bioaccumulation is expected to be low.
Key value for chemical safety assessment
Additional information
Experimental data investigating the bioaccumulation potential of
Fatty acids, C16-18 and C18-unsatd., ethyl esters (CAS 85049-36-1) are
not available. The substance has a log Pow 8.51 indicating a potential
to bioaccumulate in biota. However, the information gathered on
environmental behaviour and metabolism in combination with the
QSAR-estimated BCF values provide enough evidence (in accordance with
REACh Regulation (EC) No. 1907/2006, Annex XI General rules for
adaptation of the standard testing regime set out in Annexes VII to X,
1.2, to cover the data requirements of Regulation (EC) No. 1907/2006,
Annex IX) to state that the substances is not likely to bioaccumulate.
The substance is considered to be readily biodegradable and is insoluble
in water (water solubility < 0.05 mg/L). According to the Guidance on
information requirements and chemical safety assessment, Chapter R.7b,
readily biodegradable substances can be expected to undergo rapid and
ultimate degradation in most environments, including biological Sewage
Treatment Plants (STPs). The guidance document states furthermore that
once insoluble chemicals enter a standard STP, they will be extensively
removed in the primary settling tank and fat trap and thus, only limited
amounts will get in contact with activated sludge organisms (ECHA,
2012). Therefore, after passing through conventional STPs, only low
concentrations of these substances are likely to be (if at all) released
into the environment.
If released to the water the substance will tend to bind to sediment and
other particulate organic matter due to their hydrophobicity and
relatively high adsorption potential. Thus, the most relevant exposure
route for aquatic organisms such as fish will be via food ingestion or
contact with suspended solids. If the substance is ingested by organisms
a fast metabolisation is expected. The substance is expected to be
hydrolysed by lipases. The resulting free fatty acids and alcohols are
absorbed from the intestine into the blood stream. The alcohols are
metabolised primarily in the liver through a series of oxidative steps,
finally yielding carbon dioxide (Berg, 2001; HSDB). Fatty acids are
either metabolised via the beta-oxidation pathway in order to generate
energy for the cell or reconstituted into glyceride esters and stored in
the fat depots in the body (Berg et al., 2001). Lipids and their
constituents, fatty acids, are in particularly a major organic
constituent of fish and play major roles as sources of metabolic energy
(Tocher, 2003). The main route of excretion is via expired air as CO2,
and the second route of excretion is by biliary excretion and faeces. In
a study conducted Fatty acids, C16-18 and C18-unsatd., ethyl esters
14C-labeled carbon of 5 mL/kg of Fatty acids, C16-18 and C18-unsatd.,
ethyl esters (CAS 85049-36-1) was rapidly excreted in respiration CO2
(approximately 70%), faeces (7 -10%), and urine (1-2%), with essentially
complete elimination by 72 hours after administration (Bookstaff, 2003).
Estimated bioconcentration (BCF) and bioaccumulation (BAF) values
were calculated for the substance using the BCFBAF v3.01 program
(Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10., US
EPA), assuming biotransformation (Arnot-Gobas method). The estimated BCF
values of the main components ranged from 13.08 - 25.17 L/kg. The
estimated BAF values of the main components ranged from 252.8 - 691.9
L/kg. Both values indicate a low bioaccumulation of the substance.
A detailed reference list is provided in the technical dossier (see
IUCLID, section 13) and within the CSR.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.