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EC number: 213-367-9 | CAS number: 939-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Human repeated insult patch test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butylbenzaldehyde
- EC Number:
- 213-367-9
- EC Name:
- 4-tert-butylbenzaldehyde
- Cas Number:
- 939-97-9
- Molecular formula:
- C11H14O
- IUPAC Name:
- 4-tert-butylbenzaldehyde
- Details on test material:
- - Name of test material (as cited in study report): p-tert-butylbenzaldehyde
- Analytical purity: no data given
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 60
- Sex: 26 males and 34 females
- Age: 16 - 72 years
The selection of the subjects was based on the following criteria:
Absense of any physical or dermatological condition which would preclude application of the test material - Route of administration:
- dermal
- Details on study design:
- A. INDUCTION EXPOSURE
- Site: inner aspect of the arm or the back between scapulae and the waist (2 cm2)
- Exposure period: removal of the patch after 24 hours
- Rest period: Twenty-four hour rest periods followed the Tuesday and Thursday removals and 48 hour rest periods followed the Saturday removal.
- Frequency of applications: 10
- The test site was scored just prior to the next patch application. The choice of contact site for the second and subsequent applications depended on the condition of the previous site. Thus, if no irritation was observed at this time, the test material was reapplied to the same site . If, however, at least a 2+ reaction was observed, the test material was applied to a new site and the change in site was recorded . If a minimum of a 2+ reaction occurred in the new site, no new exposures were made.
- Concentration: 2 % (about 200 mg)
- Control group: no
B. CHALLENGE EXPOSURE
- Day(s) of challenge: ten to fourteen days after application of the last induction patch
- Exposure period: the patches remained in place for 24 hours
- Site: original contact site of the induction and a fresh, adjacent site
- Concentrations: 2 % (about 200 mg)
- Evaluation (hr after challenge): the sites were scored 24 and 48 hours after application
- Control group: no
Results and discussion
- Results of examinations:
- Nine subjects did not complete the test for personal reasons and not because of adverse reactions to the test product. Fifty one subjects completed the test .
The test material elicited no adverse dermal reactions from any of the subjects. It appears that the test material is not capable of inducing sensitization effects on the skin under the chosen testing conditions.
Applicant's summary and conclusion
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