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EC number: 205-855-5 | CAS number: 156-43-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: Key study: p-Phenetidine was considered as slightly irritant by the Cosmetic and AFNOR protocols and non-irritant by OECD (skin irritation)
Eye irritation: According to the AFNOR protocol, p-phenetidine is very irritating (without rinsing) (eye irritation).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Key study: experimental result: test according to the method published by the French authorities for the testing of cosmetics and toiletries (Journal Officiel 21 April 1973) and the methods proposed for the testing of chemicals by the Association Francaise de Normalisation (AFNOR) and, in 1979, by the Organisation for Economic Cooperation and Development.
The primary cutaneous irritation of 56 chemicals was tested in the rabbit using three different procedures. The results of the three sets of tests were compared and the effects of differences in procedure and numbers of animals were studied, together with the possible relation between irritancy and the pH of the test material. It was concluded that the AFNOR protocol best met the requirements for such tests and that gloves should be worn for the handling of all substances classified as moderately or severely irritant on that scale.
p-Phenetidine was considered as slightly irritant by the Cosmetic and AFNOR protocols and non-irritant by OECD.
Key study: experimental result: test according to the proposed by the Association Francaise de Normalisation (AFNOR) in 1982 and by the Organisation for Economic Cooperation and Development in 1979 for the testing of chemicals and that published by the French authorities (Journal Officiel 21 April 1971) for the testing of cosmetics and toiletries.
The ocular irritancy of 56 chemicals was tested in the rabbit eye, with and without rinsing, using three different procedures. The results obtained were used to establish the extent to which the assessment of a chemical's irritation potential was affected by the differences between the three protocols in respect of the observation times prescribed, the inclusion and timing of rinsing, the number of animals used and the interpretation procedure. Conclusions were also drawn about the influence of the physical state and pH of a material on its potential irritancy and about the level of irritancy that necessitates the use of eye protection.
The experience has shown that the various ocular irritation indices are not a particularly helpful guide in themselves; a graduated scale of irritancy taking into account both these indices and the reversibility of the lesions seems a preferable basis for the interpretation of results.
According to this paper, the AFNOR protocol best meets these criteria. According to the AFNOR protocol, p-phenetidine is very irritating (without rinsing).
Effects on eye irritation: highly irritating
Justification for classification or non-classification
The substance is included in Table 3 of Annex VI of CLP Regulation (harmonised classification and labelling) and classified as:
Eye irritation Category 2
The available information on skin and eye irritation studies supports the classification as Eye irritant Category 2 and the no classification for skin irritation.
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