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EC number: 233-036-2 | CAS number: 10025-67-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This study is not reliable due to methodological deficiencies and therefore inappropriate for a toxicological assessment of disulphur dichloride. (No analytical verification of test atmosphere, solvent methylene chloride; one rat, one rabbit and one guinea pig histopathologically investigated and autopsy reported to showed pulmonary and bronchial inflammation, congestion and strong inflammatory symptoms in the kidneys and effects on liver and kifney (no further data). in rat and rabbits. No effects were reported in guinea pig; Gross 1944.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 944
- Report date:
- 1944
Materials and methods
- Principles of method if other than guideline:
- 2 rabbits, 2 guinea pigs, 2 rats were exposed in a 2 m³ vessel to disulphur dichloride vapour of 0.1 mm³/L for 4 hours. The test was repeated per over 25 days. Observation for clinical signs, post exposure histopathological examination.
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
Test material
- Reference substance name:
- Disulphur dichloride
- EC Number:
- 233-036-2
- EC Name:
- Disulphur dichloride
- Cas Number:
- 10025-67-9
- Molecular formula:
- Cl2S2
- IUPAC Name:
- dichlorodisulfane
- Details on test material:
- - Name of test material (as cited in study report): disulphur dichloride
- Analytical purity: not reported
Constituent 1
Test animals
- Species:
- other: rat, rabbit, guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: 10 % solution of test substance in dichloromethane
- Remarks on MMAD:
- MMAD / GSD: not applicable
- Details on inhalation exposure:
- Daily exposure was 4 hour, after every hour the test chamber was ventilated and the test atmosphere reconstituted with 0.1 mm³/liter test substance
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 25 days
- Frequency of treatment:
- 4 hours/day over 25 day-exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 mm³/L dissolved in methylene chloride
Basis:
nominal conc.
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: no
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Sacrifice and pathology:
- All animals except 1 rabbit which died after 14 days received 25 exposures. Afterwards the second rabbit, 1 guinea pig and 1 rat were sacrified and examined histopatologically.
- Other examinations:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Details on results:
- The most of the animals showed no symptoms during the duration of the experiments. However, in 1 rabbit increased protein content in urine on day 12 of exposure, it visibly lost weight and was found dead on the morning after the 14th day of the experiment. The autopsy showed pulmonary and bronchial inflammation, congestion and strong inflammatory symptoms in the kidneys (glomorulo-tubular nephritis with bleeding). After cessation of the exposure 1 rabbit, 1 guinea pig and 1 rat were examined histopathologically. Effects on liver and kidney (no further data) in rat and rabbits were noted. No effects were reported in guinea pig.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The most of the animals showed no symptoms during the duration of the experiments. However, in 1 rabbit increased protein content in urine on day 12 of exposure, it visibly lost weight and was found dead on the morning after the 14th day of the experiment. The autopsy showed pulmonary and bronchial inflammation, congestion and strong inflammatory symptoms in the kidneys (glomorulo-tubular nephritis with bleeding). After cessation of the exposure 1 rabbit, 1 guinea pig and 1 rat were examined histopathologically. Effects on liver and kidney (no further data) in rat and rabbits were noted. No effects were reported in guinea pig.
Applicant's summary and conclusion
- Executive summary:
2 rabbits, 2 guinea pigs, 2 rats were exposed in a 2 m³ vessel to disulphur dichloride vapour of 0.1 mm³/L for 4 hours. The test was repeated per over 25 days. Observation for clinical signs, post exposure histopathological examination.
The most of the animals showed no symptoms during the duration of the experiments. However, in 1 rabbit increased protein content in urine on day 12 of exposure, it visibly lost weight and was found dead on the morning after the 14th day of the experiment. The autopsy showed pulmonary and bronchial inflammation, congestion and strong inflammatory symptoms in the kidneys (glomorulo-tubular nephritis with bleeding). After cessation of the exposure 1 rabbit, 1 guinea pig and 1 rat were examined histopathologically. Effects on liver and kidney (no further data) in rat and rabbits were noted. No effects were reported in guinea pig.
This study is not reliable due to methodological deficiencies and therefore inappropriate for a toxicological assessment of disulphur dichloride. (No analytical verification of test atmosphere, solvent methylene chloride; one rat, one rabbit and one guinea pig histopathologically investigated and autopsy reported to showed pulmonary and bronchial inflammation, congestion and strong inflammatory symptoms in the kidneys and effects on liver and kifney (no further data). in rat and rabbits. No effects were reported in guinea pig; Gross 1944.
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