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EC number: 228-391-5 | CAS number: 6258-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The test substance is an odourless, red solid/powder with a molecular weight of 404.17 g/mol and a log Pow of -0.53 at 25°C. Its water solubility is about 20 g/L at 15 - 20°C.
In two acute oral toxicity study, rats were treated orally with the test substance at 5000 and 20000 mg/kg bw. Clinical signs or deaths were not reported. In two subacute oral toxicity studies, male and female rats were treated with the test substance at concentrations of 40 – 1000 mg/kg bw. At 200 mg/kg bw slight hepatocytomegaly, hyaline droplets and intraepithelial eosinophilic cytoplasmic inclusions in the tubulus epithelium were observed in the male rats. At 1000 mg/kg bw reduced weight gain, reduced food intake, reduced erythrocyte count, reduced haemoglobin and haematocrit content, increased spleen weight, congestion, increased extramedullary hematopoiesis were observed in male and female animals (Bayer 21366). In the second study, no death was observed, but from 3rd week of treatment, squatting position, decreased food intake and a decrease of mean body weights by up to 12 % were observed. Clinical signs that were obvious in the first study indicate that absorption of the test substance along the gastro intestinal tract and hence systemic exposure is possible. This assumption is supported by the physico-chemical parameters of the test substance: a molecular weight below 500, the hydrophilic properties, the sulphonate functional group and hence the good water solubility are favourable for GIT-absorption (ECHA, R7c).
Dermal uptake might be unlikely with regard to the molecular weight of the test substance, and anticipated to be low to moderate with regard to the water solubility. Furthermore, the log Pow indicates poor lipophilicity which limits penetration into the stratum corneum and hence dermal absorption (ECHA, R7c). In addion, irritating effects of the test substance were not observed (damage to the skin surface may enhance penetration) (Bayer 1979, Marhold 1972).
No data on inhalative toxicity of the test substanceis available, but the log Pow of -0.53 favours absorption across the respiratory tract epithelium by passive diffusion. On the other hand, the hydrophilic properties of the test substance are indicative for retention within the mucus.
Overall, the substance is considered to be non bioaccumulating.
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