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EC number: 277-242-0 | CAS number: 73037-34-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Disodium oxybis[methylbenzenesulphonate]
- EC Number:
- 277-242-0
- EC Name:
- Disodium oxybis[methylbenzenesulphonate]
- Cas Number:
- 73037-34-0
- Molecular formula:
- C14H12Na2O7S2
- IUPAC Name:
- disodium oxybis(methylbenzenesulfonate)
- Test material form:
- solid
- Details on test material:
- Active content reported: 90-95 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: animal 1: 19 weeks, animal 2: 34 weeks, animal 3: 30-31 weeks
- Weight at study initiation: > 2 kg
- Diet ad libitum
- Water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18
- Humidity (%): 55
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated eye of each animal served as control.
- Amount / concentration applied:
- 100 mg
- Duration of treatment / exposure:
- once
- Observation period (in vivo):
- up to 6 days
- Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- The test item was applied at a single dose (100 mg) into the conjunctival sac of one eye of each test animal after pulling the lower lid away from eyeball. The lids were then gently held together for about 1 sec in order to prevent loss of the material. The untreated contralateral eye served as control. The treated eye was not rinsed. The eyes were examined for signs of irritation throughout the observation period. The eye irritation was scored according to Draize.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- >= 0.67 - <= 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 6 days
- Remarks on result:
- other: animal 1: score 1 of max 3 for 72 h; animal 2: score 1 for 48 h: amimal 3: score 1 for 72 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: up to 72 hours
- Score:
- ca. 0
- Max. score:
- 4
- Irritant / corrosive response data:
- The only effects observed: Some blood vessels were hyperaemic (conjunctival injections, score 1 of max 3), which was fully reversible within 6 days.
- Other effects:
- no effects reported
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Conclusions:
- The animals showed slightly irritation effects which were fully reversible within 6 days and which do no lead to classification.
- Executive summary:
Ditolylether disulfonic acid disodium salt, isomer mixture was tested for eye irritating property using 3 female New Zealand White rabbits. The test item was applied at a single dose (100 mg, undissolved) into the conjunctival sac of one eye of each test animal after pulling the lower lid away from eyeball. The lids were then gently held together for about 1 sec in order to prevent loss of the material. The untreated contralateral eye served as control. The treated eye was not rinsed. The eyes were examined for signs of irritation throughout the observation period. The eye irritation was scored according to Draize. The animals showed slightly irritation effects (conjunctival injections) most probabely due to mechanical irritation by the undissolbed substance. These effects were fully reversible within 6 days and do no lead to classification.
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