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EC number: 201-152-2 | CAS number: 78-87-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 6, 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The GLP study was not conducted according to guideline/s but the report contains sufficient information to permit a meaningful evaluation of study results
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- none
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- - Name of test material (as cited in study report): Propylene dichloride
- Substance type: solvent, chemical intermediate and fumigant
- Physical state: liquid
- Analytical purity: 99 %
- Lot/batch No.: 82TA 820401 LSS
Constituent 1
Test animals
- Species:
- other: rat and mice
- Strain:
- other: Fischer 344 rats and B6C3F1 mice
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fischer 344 rats and B6C3F1 mice (Charles River Breeding Laboratories)
- Age at study initiation: 16-17 weeks old
- Weight at study initiation: rats (mean: 279-286 g), mice (mean: 30-32 g)
- Housing: not specified in the report
- Diet (e.g. ad libitum): ad libitum, except during exposure
- Water (e.g. ad libitum): ad libitum, except during exposure
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not specified in the report
- Humidity (%): not specified in the report
- Air changes (per hr): not specified in the report
- Photoperiod (hrs dark / hrs light): not specified in the report
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Glass J-tube method
- Exposure chamber volume: 4.3 m3 stainless steel and glass Rochester-type chambers
- Source and rate of air: filtered air, chamber airflow maintained at ~ 800 l/min
- Method of conditioning air: flitered
- Temperature, humidity, pressure in air chamber: maintained at approximately 70 °F and 50 %.
TEST ATMOSPHERE
- Brief description of analytical method used: The concentration of propylene dichloride in each exposure chamber was determined at least 2 times/hr with a MIRAN 1A infrared spectrophotometer at a wavelength of 9.8 µ. The concentration of propylene dichloride in the chamber was determined by interpolation from a standard curve derived from known air standards.
- Samples taken from breathing zone: not specified in the report
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- The analytical time weighted average concentrations for the single 6-hour exposure were 500 and 1498 ppm for the targeted concentrations of 500 and 1500 ppm.
- Duration of exposure:
- ca. 6 h
- Concentrations:
- 500 and 1500 ppm
- No. of animals per sex per dose:
- 5 males rats/mice per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 4 days
- Frequency of observations and weighing: All animals observed before, during and after exposure. Bodyweights recorded on the day of exposure, days 2 and 4
- Necropsy of survivors performed: yes
- Other examinations performed: gross pathology and histopathology - Statistics:
- No statistical analyses performed
Results and discussion
- Preliminary study:
- none
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 500 ppm
- Exp. duration:
- 6 h
- Remarks on result:
- other: B6C3F1 mice
- Sex:
- male
- Dose descriptor:
- other: LC50 could not be determined
- Effect level:
- 500 - 1 500 ppm
- Exp. duration:
- 6 h
- Remarks on result:
- other: Fischer 344 rats
- Mortality:
- Rats - no mortality
Mice - All mice (5/5) exposed to 1500 ppm died within 24 hours post exposure and 2/5 mice exposed to 500 ppm died during the post exposure period - Clinical signs:
- other: Rats - 1500 ppm - appeared anesthetized/lethargic during exposure, 500 ppm - all animals appeared normal Mice - 1500 ppm - mortality within 24 hours post exposure, 500 ppm - surviving animals appeared normal
- Body weight:
- Rats - 1500 ppm - slightly greater body weight loss as compared to control animals on the day of exposure, howvever, subsequent body weight gain comparable to controls. 500 ppm - comparable body weights to controls
Mice - 500 ppm - comparable body weights to controls - Gross pathology:
- Rats - 1500 ppm - slight pallor of the liver observed in 4/5 rats, 500 ppm - no gross pathological changes observed
Mice - 1500 ppm - no gross pathological changes 5/5 (found dead), 500 ppm - grossly visible liver lesions 2/3 (terminal sacrifice) - Other findings:
- - Histopathology:
Rats - slight pallor of liver noted was correlated histopathologically with a slightly increased degree of microvacuolization of the hepatocytes. other changes noted in liver and kidney were considered normal.
Mice - Gross indications (varied intensity) of hepatotoxicity with extensive acute hemorrhagic coagulation necrosis of the liver seen in 2/3 surviving animals exposed to 500 ppm
Any other information on results incl. tables
see the attached word doc. for tables and figures:
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results of the study, Propylene dichloride may be classified as harmful by inhalation, according to Annex VI-Directive 67-548/EEC.
- Executive summary:
An Acute Vapor Inhalation Toxicity Study (no guidelines followed) and conforming to GLP) of Propylene Dichloride (purity: 99% and lot no.: 82TA 820401 LSS) in male Fischer 344 rats and B6C3F1 mice (16-17 weeks old), sourced from Charles River Breeding Laboratories, were exposed to 0, 500 and 1500 ppm for a single 6-hour exposure. The analytical time weighted average concentrations for the single 6-hour exposure were 500 and 1498 ppm, respectively. Animals were acclimated to laboratory conditions and were housed in standard conditions and fed with standard diet (Certified Purina Chow #5002) and water provided ad libitum, except during exposure. Parameters evaluated were during the 4-day observation period included body weights and in-life observations. All animals were examined for gross pathological changes.
Rats exposed to 1500 ppm were lethargic during exposure, lost weight and exhibited pale liver on gross examination. All mice exposed to 1500 ppm died within 24-hours post-exposure and exhibited non-specific changes typical of animals which die in acute studies. Several mice exposed to 500 ppm of propylene dichloride died and exhibited various degrees of liver toxicity upon gross and histopathological examination. The acute LC50 for mice was determined to be approximately 500 ppm with observation of liver toxicity. Also, species differences in sensitivity of rats and mice were observed.
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