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EC number: 233-038-3 | CAS number: 10025-73-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well documented summary of different GLP toxicological studies (following OECD protocols) performed with niacin-bound chromium (III) complex
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 64452-96-6
- Cas Number:
- 64452-96-6
- IUPAC Name:
- 64452-96-6
- Reference substance name:
- Chromium(3+) tri(pyridine-3-carboxylate)
- IUPAC Name:
- Chromium(3+) tri(pyridine-3-carboxylate)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Niacin bound chromium (NBC) is a unique, patented oxygen-coordinated niacin-bound chromium complex commercially known as ChromeMate CM-100M (powder) and was obtained from InterHealth Nutraceuticals, Benicia, CA, USA.
Lot#306013
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Five male rats and five nulliparous and non-pregnant female rats (body weight: 298–310 and 199–205 g, respectively) were received from Ace Animals, Inc., (Boyertown, PA, USA) and allowed free access to lab chow (Purina Rodent Chow No. 5012, St. Louis, MO, USA) and municipal water ad libitum. Animals were acclimated to laboratory conditions for 13 days prior to initiation of dosing. The animal room was kept at a controlled temperature (18–22 °C) and light (12 h light/12 h dark).
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Remarks:
- test product was moistened with distilled water to achieve a dry paste by preparing a 70% w/w mixture
- Details on dermal exposure:
- Individual doses of the NBC were calculated based on the initial body weights obtained prior to dosing with a 2000 mg/kg b.w. On the day prior to application, the hair was removed by clipping the dorsal area and the trunk using an Oster model #A5-small clipper. After clipping and prior to application, the animals were examined for health, weighed (initial) and the skin checked for any abnormalities. The NBC test product was moistened with distilled water to achieve a dry paste by preparing a 70% w/w mixture. The NBC was then applied to a 2 in. * 3 in., 4-ply gauze pad and placed on the animal (approximately 10% of the body surface). The gauze pad and entire trunk of each animal were then wrapped with 3-in. Durapore tape to avoid dislocation of the pad and to minimize loss of the test substance.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- The day of application was considered Day 0 of the study. After 24 h of exposure to the test substance, the pads were removed and the test sites were gently cleansed of any residual test substance. Individual body weights of the animals were recorded prior to test substance application (initial) and again on Days 7 and 14 (termination). Necropsies were performed on all animals at terminal sacrifice. The animals were observed for mortality, signs of gross toxicity, and behavioral changes after application and at least once daily thereafter for 14 days. Observations included gross evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity, and behavior pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhea and coma. All rats were euthanized via CO 2 inhalation on Day 14. Gross necropsies were performed on all animals. Tissues and organs of the thoracic and abdominal cavities were examined.
- Statistics:
- no statistics applied due to absence of effects
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality was observed
- Clinical signs:
- other: no adverse clinical signs were observed, animals remained active and healthy
- Gross pathology:
- No gross abnormalities were noted for any of the animals at necropsy.
- Other findings:
- There were no signs of gross toxicity, dermal irritation, adverse pharmacologic effects or abnormal behavior.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal toxicity to rats was found as LD50 >2000 mg/kg bw. No mortality occured and no adverse effects were noted.
- Executive summary:
In this acute dermal toxicity study using Sprague-Daley male and female rats, exposed to 2000 mg/kg bw did not show mortality, clinical signs of toxicity or pathological alterations upon gross necropsy. Body weight development also was not affected by treatment. Thus, the acute dermal LD50 was set to >2.000 mg/kg bw and the substance was considered not classified according to CLP (Regulation EC No 1272/2008).
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