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Diss Factsheets
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EC number: 272-250-0 | CAS number: 68784-48-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Due to the degradation when mixed in water, it is considered valid to only assess the aquatic toxicity of the degradation products. A review of the components demonstrates that only triethanolamine has any significant toxicity to aquatic organisms and review of data has concentrated on this component.
A PNEC has been set using the triethanolamine component, present in molar ratio at < 50% w/w in the substance. Limited chronic aquatic toxicity has been found, but one reference noted that suggests Daphnia reproductive effect at 16 mg/l for triethanolamine. This study has also been cited in the disseminated dossier for triethanolamine (Source: European Chemicals Agency,http://echa.europa.eu/) and has been used to set a PNEC of 32 mg/l.
PNEC estimates for propan-2-ol is estimated and propylene glycol are reported at over 100 mg/l, so these are not considered to be contributing to any hazard from the substance. Source: European Chemicals Agency,http://echa.europa.eu/. These have not been reviewed in detail.
There has been extensive research on titanium dioxide pigments and a review by the US EPA has been used as a source of information (UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES)
http://www.epa.gov/opprd001/inerts/titaniumdioxide.pdf
“The available ecotoxicity data on titanium dioxide are primarily limited to acute aquatic toxicity studies. The acute aquatic LC,, of titanium dioxide in is reported to be >I000 mg/L based on water accommodated fraction (ECOTOX 2002). Based on the insoluble nature of titanium dioxide in water and the low acute toxicity of titanium dioxide to freshwater fish, there are no non-target aquatic species risk concerns resulting from the use of titanium dioxide as an inert ingredient. Based on the lack of absorption as well as no identified toxicological effects of concern in animal testing, there are also no risk concerns for non-target terrestrial organisms resulting from the use of titanium dioxide as an inert ingredient.”
A titanate complex has been extensively tested and data is used as part of the read-across process. This is for the substance Titanium complexes of ammonium lactate, triisopropanolamine and polyethylene glycol, CAS 1072830-14-8. This demonstrates the limited toxicity of this class of substance, even though it is questionably whether aquatic studies should have been attempted for this substance without pre-hydrolysing in accordance with OECD guideline 23 on testing of difficult substances.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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