Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-344-1 | CAS number: 21351-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP, equivalent or similar to OECD and EU guideline.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute toxicity of cesium and rubidium compounds
- Author:
- Johnson, G.T.; Lewis, R.T. and Wagner, W.D.
- Year:
- 1 975
- Bibliographic source:
- Toxicology and applied pharmacology 32, 239-245 (1975)
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Caesium hydroxide
- EC Number:
- 244-344-1
- EC Name:
- Caesium hydroxide
- Cas Number:
- 21351-79-1
- Molecular formula:
- CsHO
- IUPAC Name:
- caesium hydroxide
- Reference substance name:
- Cesium hydroxide
- IUPAC Name:
- Cesium hydroxide
- Test material form:
- solid: crystalline
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0 to 3.0 kg
Test system
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL
- Concentrations: 0.1, 0.5 and 5.0 %
VEHICLE
CsOH was dissolved in deionized-distilled water on a weight-to-weight basis prior to administration. - Duration of treatment / exposure:
- Single treatment for either 5 min or 24 hr before washing.
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 5 min treatment: 5 animals
24 h treatment: 3 animals
Sex not specified. - Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: Eyes were washed with a gentle, continuous stream of distilled water until a volume of approximately 250 mL was used.
- Time after start of exposure: 5 min or 24 h
SCORING SYSTEM:
Grades were assigned for the presence and/or degree of ulceration or opacity of the cornea and iris for redness (erythema), chemosis and ulceration or necrosis of the conjunctival mucosa according to the method of Draize. The eyes were examined at 1, 24, 48 , and 72 h at 7 days. If any injury persisted, the animals were re-examined at 24 and/or 21 days.
TOOL USED TO ASSESS SCORE:
The eyes were examined with the aid of fluorescein but without the aid of a hand slit-lamp.
Results and discussion
In vivo
Results
- Remarks on result:
- other: CsOH (5%) is considered extremely irritating and corrosive to the rabbits eye. Due to the severely of the effects no clear scores could be evaluated. 0.5 % CsOH produced no ocular reaction in the eye of rabbits.
- Irritant / corrosive response data:
- CsOH (5%) is considered extremely irritating and corrosive to the rabbits eye. Due to the severely of the effects no clear scores could be evaluated. Based on the marked response, an attempt was made to determine the concentration that produced no ocular reaction. 0.5 % CsOH produced no ocular reaction in the eye of rabbits.
- Other effects:
- One animal died in the high dose group (5%).
Applicant's summary and conclusion
- Interpretation of results:
- Category I
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based in the results obtained cesium hydroxide (5%) is considered extremely irritating and corrosive to the rabbits eye. Based on the marked response, an attempt was made to determine the concentration that produced no ocular reaction. 0.5 % CsOH produced no ocular reaction in the eye of rabbits.
- Executive summary:
In a primary eye irritation study, 0.1 mL of cesium hydroxide (0.1, 0.5 and 5.0 %) in water was instilled into the conjunctival sac of the eye of albino rabbits (in total eight animals) for 5 min or 24 hours. Eyes were washed with water after the exposure period. Animals then were observed for 21 days. Irritation was scored by the method of Draize. CsOH (5%) is considered extremely irritating and corrosive to the rabbits eye. Based on the marked response, an attempt was made to determine the concentration that produced no ocular reaction. 0.5 % CsOH produced no ocular reaction in the eye of rabbits.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)