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EC number: 257-182-1 | CAS number: 51410-72-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Experimental toxicokinetic studies are not available for MAPTAC.
The physicochemical properties of MAPTAC (log P = -2.58, high water solubility) and the molecular weight of 220.74 g/mol are suggestive of absorption from the gastro-intestinal tract. Dermal absorption is expected to be low. Inhalative absorption is not considered a relevant route of exposure due to the very low vapour pressure of the substance.
Based on physicochemical properties, no potential for bioaccumulation is to be expected.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
Additional information
Experimental toxicokinetic studies are not available for MAPTAC. Thus, the assessment of toxicokinetics is based on the physicochemical properties of the substance.
Absorption
Oral absorption
The physicochemical properties of MAPTAC (log P = -2.58, high water solubility) and the molecular weight of 220.74 g/mol are in a range suggestive of absorption from the gastro-intestinal tract subsequent to oral ingestion. Although it is generally anticipated that ionised substances do not readily diffuse across biological membranes, for chemical safety assessment an oral absorption rate of 100% is assumed as a worst case default value in the absence of other data.
Dermal absorption
Based on physicochemical properties (log P <0 and water solubility > 10 g/L) MAPTAC is likely to be too hydrophilic to cross the lipid rich environment of the stratum corneum. Thus, dermal uptake is expected to be low. However, no reliable data are available. Thus, for chemical safety assessment a dermal absorption rate of 100% is assumed as a worst case default value in the absence of other data.
Inhalative absorption
Due to the very low vapour pressure of MAPTAC (the estimated vapour pressure of MAPTAC is 2.52E-07 Pa at 25°C), exposure via inhalation is highly unlikely and thus not taken into account for chemical safety assessment.
Distribution
As a small molecule a wide distribution can be expected. No information on potential target organs is available. However, as an ionised molecule, the substance is thought to not readily diffuse across biological membranes.
Metabolism and excretion
It is very difficult to predict the metabolic changes a substance may undergo on the basis of physico-chemical information alone.
However, based on the structure, the substance is likely to undergo hydrolysis by amidases, which in general have a broad substrate specificity. Amidases are a group of non-specific enzymes that are widely distributed throughout the body and are known to show high activity within many tissues and organs. Hydrolysis of MAPTAC would result in Methacrylic acid and Aminocholine and finally Choline.
(CF READ-ACROSS DATA ON METHACRYLIC ACID AND METHYL METHACRYLATE).
Methacrylic acid is cleared rapidly from blood by standard physiological pathways, with the majority of the administered dose being exhaled as CO2.
Choline is a naturally occurring component which contributes to vital biological functions, e.g. the synthesis of phospholipids, which are structural cell components, as precursor for the intracellular messenger molecules, and for acetylcholine. Choline produced from MAPTAC-metabolism would be indistinguishable from Choline from other sources. Thus, further considerations on excretion are not necessary.
Bioaccumulation
Based on the low log P the substance is unlikely to accumulate with the repeated intermittent exposure patterns normally encountered in the workplace.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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