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EC number: 939-714-0 | CAS number: 1474044-77-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study followed guidelines appropriate at the time of the study. 10 animals were tested at the very high concentration of 200 mg/L and no toxicity was evident.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Acute Inhalation Study. US FHSLA, CFR, Title.21, para. 191.10.
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- di C8-C10, branched, C9 rich, alkylnaphthalene sulphonic acid
- EC Number:
- 939-714-0
- Cas Number:
- 1474044-77-3
- Molecular formula:
- C18H30SO3 to C40H67SO3
- IUPAC Name:
- di C8-C10, branched, C9 rich, alkylnaphthalene sulphonic acid
- Test material form:
- other: used as 50% solution in light naphthenic petroleum oil
- Details on test material:
- Synex 1052 (black-brown I iquid):
50% DNNSA (DI C8-C10, BRANCHED, C9 RICH, ALKYLNAPHTHALENE SULFONIC ACID)
50% Light Naphthalenic Petroleum Oil
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The spray was introduced into the chamber via a nebulizer, was circulated and was directed away from the animals. The chamber was saturated with 200mg/liter.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Five male and five female Wistar rats, 200 - 300g. A group of five male and five female Wistar rats were exposed to an aerosol
of the test material in an inhalation chamber for one hour. The spray was introduced into the chamber via a nebulizer, was circulated and was directed away from the animals. The chamber was saturated with 200mg/liter, nominal, of test material prior to the period of exposure.
The rats were observed for 14 days following exposure.
exposu reo - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 1 h
- Concentrations:
- 200 mg/L
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Statistics:
- None Required
Results and discussion
- Preliminary study:
- The study was a limit test without a preliminary exposure.
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 200 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 100 mg/L air
- Based on:
- act. ingr.
- Exp. duration:
- 1 h
- Mortality:
- No mortality
- Clinical signs:
- other: No clinical symptoms or other adverse effects
- Body weight:
- See table - attached
- Gross pathology:
- No remarkable findings.
Any other information on results incl. tables
Body Weights of Wistar Rats
Rat No. |
Sex |
Body Weight - grams |
Mortality |
1 |
M |
230 |
No |
2 |
M |
241 |
No |
3 |
M |
256 |
No |
4 |
M |
267 |
No |
5 |
M |
280 |
No |
6 |
F |
214 |
No |
7 |
F |
217 |
No |
8 |
F |
225 |
No |
9 |
F |
232 |
No |
10 |
F |
230 |
No |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: other: EPA Category IV ( practically non-toxic based on LC50 greater than 20 mg/L)
- Conclusions:
- A one-hour exposure to a 50% formulation of DNNSA at 200 mg/L was not toxic to male and female Wistar rats.
- Executive summary:
Synex 1052, a 50% liquid formulation of DNNSA (DI C8-C10, BRANCHED, C9 RICH, ALKYLNAPHTHALENE SULFONIC ACID), was evaluated for acute inhalation toxicity. Five male and five female Wistar rats, (Body Wt. 200 - 300g) received a whole body exposure for one hour to an aerosol of the test material in an inhalation chamber. The spray was introduced into the chamber via a nebulizer, was circulated and was directed away from the animals. The chamber was saturated with 200 mg/liter, nominal, of test material prior to the period of exposure. The rats were observed for 14 days following exposure. In the one-hour exposure, and during the 14 day observation period, the test material did not cause mortality or clinical symptoms of poisoning. The 1-hour LC50 is > 200 mg/L of the 50% formulation of DNNSA. Based on the concentration of DNNSA, the 1-hour LC50 is > than 100 mg/L. The study reports that the result support classification as EPA Category IV (practically non-toxic based on LC50 greater than 20 mg/L).
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