Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-959-9 | CAS number: 626-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro
Gene mutation in bacteria
In a bacterial reverse gene mutation assay according to GLP and OECD 471 and 472 strains TA 98, TA 100, TA 1535 and TA 1537 of S. typhimurium and E.coli WP2 uvrA were exposed to the test item (analytical purity: 80.2 %), using water as solvent, at concentrations of 25, 125, 625, 3125, 6250 µg/plate (Standard plate incubation test) and 20, 100, 500, 2500, and 5000 µg/plate (Preincubation test, 20 minutes, 37 °C) in the presence and absence of mammalian metabolic activation (liver fraction (S-9) from Aroclor 1254 induced rat) (BASF, 40M0385/964256, 1997). The test item was tested up to cytotoxic concentrations. The positive control induced the appropriate responses in the corresponding strains. There was no evidence of induced mutant colonies over background. The study is classified as acceptable (reliability 1). Despite the requirements of OECD Guideline 471 (adopted 1997), 2-Aminoanthracene was the sole positive control in the presence of S9-Mix. Cytotoxicity was observed at a concentration of > 2500 µg/plate with and without metabolic activation in the Preincubation test.
The test item was negative in the Ames test using Salmonella typhimurium strains TA98, TA100, TA 1535 and TA1537 and E.Coli WP2 uvrA with and without metabolic activation with S9 from Aroclor-induced rat liver.
Short description of key information:
in vitro
Gene mutation in bacteria
Ames test with S. typhimurium TA 98, TA 100, TA 1535, and TA 1537 as well as E.coli WP2 uvrA with and without metabolic activation: negative up to 6250 µg/plate, GLP, OECD 471 and 472, Val. 1 (BASF AG, 1997)
Endpoint Conclusion:
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available experimental test data for genetic toxicity are reliable but insufficient for the purpose of classification under Directive 67/548/EEC (only Ames test available for assessment). As a result the substance is not considered to be classified for mutagenicity under Directive 67/548/EEC due to lack of data.
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008
The available experimental test data for genetic toxicity are reliable but insufficient for the purpose of classification under Regulation (EC) No.1272/2008 (only Ames test available for assessment). As a result the substance is not considered to be classified for mutagenicity under Regulation (EC) No.1272/2008, as amended for the 2nd time in Commission Regulation (EU) No. 286/2011 due to lack of data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.