Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-986-1 | CAS number: 16924-00-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11th September 2000 to 12th September 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dipotassium heptafluorotantalate
- EC Number:
- 240-986-1
- EC Name:
- Dipotassium heptafluorotantalate
- Cas Number:
- 16924-00-8
- Molecular formula:
- F7Ta.2K
- IUPAC Name:
- Tantalate(2-), heptafluoro-, potassium (1:2)
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material: Potassium Fluorotantalate
- Physical state: Powder
- Storage condition of test material: Room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, Oxon, UK
- Age at study initiation: At least 15 weeks
- Weight at study initiation: 3064g
- Housing: Individually in a metal cage.
- Diet: standard laboratory rabbit diet (Special Diet Services STANRAB (P) SQC pellet) ad libitum.
- Water: Water supplied ad libitum from mains water supply (Anglian Water).
- Acclimation period: 11 days prior to the start of the study.
ENVIRONMENTAL CONDITIONS
- Temperature: 19 ± 2 ºC
- Humidity: 30 to 70%
- Photoperiod: 12 hours of artificial light (0600 -1800), 12 hours of darkness.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
Amount applied: 100mg - Duration of treatment / exposure:
- 100 mg of the test material was placed in the lower everted eyelid, which was gently held together for 1 second before being released. The other eye remained untreated.
- Observation period (in vivo):
- The test animal was observed one hour after administration and then at 24 hours post administration. Aided by the use of a hand light.
- Number of animals or in vitro replicates:
- 1 male
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: Irrigation was not performed.
SCORING SYSTEM:
The reaction was scored according to the Draize scale (1959) which is detailed below in the field " Any other information in materials and methods incl. tables" as table 1. Any lesion or reaction not covered by the scoring system was described.
TOOL USED TO ASSESS SCORE: hand-help lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1337
- Time point:
- other: 24 hours
- Score:
- 5
- Max. score:
- 8
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- animal: 1337
- Time point:
- other: 1 hour
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 24 hours
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1337
- Time point:
- other: 24 hours
- Score:
- 7
- Max. score:
- 7
- Reversibility:
- not specified
- Irritant / corrosive response data:
- Dulling of the cornea developing into corneal opacification (Grade 1) and iridial inflammation (Grade 1) was seen. The conjunctiva developed a beefy red colouration and swelling with lids more than half closed. Due to the severity of the ocular reaction the animal was sacrificed one day after dosing. Post-mortem testing revealed necrosis, blanching and heamorrhaging of the nictating membrane, blanching and necrosis of the conjunctivae and the stripping of epithelial cells form the cornea.
- Other effects:
- There were no other signs of toxicity or ill health in any test animal during the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, the test material caused elicited corneal opacification, iridial inflammation and considerable conjunctival irritation. The test material therefore requires classification as an eye irritant.
- Executive summary:
The eye irritation of the test material was determined in accordance with standardised guidelines OECD 405, EU Method B.5 and EPA OPPTS 870.2400. Approximately 100mg of the test material was applied directly into the eye of one rabbit, using the contralateral eye as a control; the rabbit was observed once at 1 hour post application and for the second time at 24 hours post application. The ocular reaction observed was so severe that no other animals were tested and the test animal was sacrificed one day after dosing. Elicited corneal opacification, iridial inflammation and considerable conjunctival irritation were observed.
Under the conditions of the study, the test material was considered to be of serious risk to the eyes. The test material requires classification as Irritating (Xi) with the risk phrase R41 "Risk of serious damage to eyes" under Directive 67/548/EEC. Under Regulation 1272/2208, the test material requires classification as "Eye Damage 1" with the hazard statement "H318: Causes serious eye damage".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.